6-Fluoroveratraldehyde
- CAS No.
- 71924-62-4
- Chemical Name:
- 6-Fluoroveratraldehyde
- Synonyms
- 2-FLUORO-4,5-DIMETHOXYBENZALDEHYDE;6-Fluoroveratraldehyde;6-Fluoroveratraldehyde,97%;6-FLUOROVERATRALDEHYDE, 98+%;6-Fluoro-3,4-dimethoxybenzaldehyde;4,5-DIMETHOXY-2-FLUOROBENZALDEHYDE;3,4-DIMETHOXY-6-FLUOROBENZALDEHYDE;Benzaldehyde,2-fluoro-4,5-dimethoxy-;2-Fluoro-4,5-dimethoxybenzaldehyde>4,5-Dimethoxy-2-fluorobenzaldehyde~2-Fluoro-4,5-dimethoxybenzaldehyde
- CBNumber:
- CB1732427
- Molecular Formula:
- C9H9FO3
- Molecular Weight:
- 184.16
- MDL Number:
- MFCD00061108
- MOL File:
- 71924-62-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 93-97 °C(lit.) |
|---|---|
| Boiling point | 273.3±35.0 °C(Predicted) |
| Density | 1.201±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C, stored under nitrogen |
| form | powder to crystal |
| color | White to Light yellow |
| Sensitive | Air Sensitive |
| BRN | 2109343 |
| InChI | InChI=1S/C9H9FO3/c1-12-8-3-6(5-11)7(10)4-9(8)13-2/h3-5H,1-2H3 |
| InChIKey | IBBYQNVXKFMSSI-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC(OC)=C(OC)C=C1F |
| CAS DataBase Reference | 71924-62-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29122900 | |||||||||
| NFPA 704 |
|
6-Fluoroveratraldehyde price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0441 | 2-Fluoro-4,5-dimethoxybenzaldehyde >98.0%(GC) | 71924-62-4 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | F0441 | 2-Fluoro-4,5-dimethoxybenzaldehyde >98.0%(GC) | 71924-62-4 | 5g | $91 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0023 | 6-Fluoroveratraldehyde, min. 98% min.98% | 71924-62-4 | 25g | $120 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0023 | 6-Fluoroveratraldehyde, min. 98% min.98% | 71924-62-4 | 100g | $360 | 2026-04-30 | Buy |
| Apolloscientific | PC8855 | 4,5-Dimethoxy-2-fluorobenzaldehyde ≥95% | 71924-62-4 | 1g | $32 | 2026-06-04 | Buy |
6-Fluoroveratraldehyde Chemical Properties, Uses, Production
Synthesis
Step 1: Preparation of 3,4-dimethoxyfluorobenzene
10.0 g (65.4 mmol) of 3,4-dimethoxyaniline was dissolved in 40.0 mL of HBF4 (aq 41%) and 40 mL of CH3OH. The solution was cooled to -5 °C in an ice-salt bath. 10.0 mL of n-butyl nitrite was added dropwise under electromagnetic stirring. After stirring for 90 minutes, 200 mL of cold diethyl ether was added. The solution was allowed to stand at 0 °C for 2 hours, and a solid precipitated out. The solution was filtered, washed with 50 mL of cold diethyl ether, and dried under vacuum to obtain 15.0 g (59.8 mmol) of a light purple solid, with a yield of 90%.
20.4 g (81.3 mmol) of the above solid was placed in a 250 mL round-bottom flask, connected to a receiving flask with a U-tube, and cooled in a CaCl2- ice bath. The bottom of the flask was heated with a gas lamp until the solid was completely decomposed, yielding a brown oily liquid. 10 mL of diethyl ether was added to dissolve the liquid, and it was washed once with 5 mL of 10% NaOH solution and once with 5 mL of water. The aqueous layer was extracted twice with 10 mL of diethyl ether. The organic layers were combined, dried over excess anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporation. The liquid was purified by vacuum distillation to obtain 5.2 g of a pale yellow oily liquid, with a yield of 42%.
Step 2: Preparation of 2-fluoro-4,5-dimethoxybenzaldehyde.
5.70 g (36.5 mmol)
3,4-Dimethoxyfluorobenzene was dissolved in 50 mL of CH₂Cl₂ and placed in a 250 mL three-necked flask. The flask was cooled to 0°C in an ice bath, and N₂ was bubbled through to remove air. Then, 7.8 mL of TiCl₄ dissolved in 20 mL of CH₂Cl₂ was added dropwise, followed by 6.2 mL of CH₂Cl₂ dissolved in 15 mL of CH₂Cl₂. After stirring for 30 minutes, the ice bath was removed, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was poured into a beaker containing 150 g of crushed ice. After the ice melted, the organic layer was separated, and the aqueous layer was extracted twice with 50 mL of diethyl ether. The organic layers were combined, and excess anhydrous sodium sulfate was added for drying. The mixture was filtered, and the solvent was removed by rotary evaporation to obtain a yellow solid. The solid was then recrystallized with a mixture of diethyl ether and petroleum ether, and dried under vacuum to obtain 4.01 g (21.8 mmol) of a pale yellow solid, with a yield of 60%.Chemical Properties
White to slightly yellow crystalline powder
Uses
6-Fluoroveratraldehyde is used in the preparation of 6-[18F]fluoroveratraldehyde via nucleophilic aromatic substitution by [18F]fluoride. It is also used in the preparation of key metabolites of 6-fluoro-DOPA.
6-Fluoroveratraldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Movin Pharmaceutical Co., Ltd. | 13681854265 | info@moenpharm.com | China | 488 | 55 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9992 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from 6-Fluoroveratraldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 2-fluoro-4,5-dimethoxybenzaldehyde
71924-62-4
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-fluoro-4,5-dimethoxybenzaldehyde
71924-62-4
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
