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ChemicalBook >> CAS DataBase List >>N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Structure
N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol structure
CAS No.
106946-74-1
Chemical Name:
N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol
Synonyms
BOC-L-ISOLEUCINOL;BOC-ILE-OL;BOC-LLE-OL;Boc-L-Ile-OL;BOC-ISOLEUCINOL;BOC-L-isoleuinol;N-BOC-L-ISOLEUCINOL;N-Boc-L-isolucinole;N-T-BOC-L-ISOLEUCINOL;N-ALPHA-T-BOC-L-ISOLEUCINOL
CBNumber:
CB1733404
Molecular Formula:
C11H23NO3
Molecular Weight:
217.31
MDL Number:
MFCD00235929
MOL File:
106946-74-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:46:25
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N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Properties

Boiling point 121-126 °C0.6 mm Hg
Density 0.984±0.06 g/cm3(Predicted)
refractive index n20/D 1.455
Flash point >230 °F
storage temp. Sealed in dry,2-8°C
solubility Soluble in water or 1% acetic acid
form Powder
pka 12.11±0.46(Predicted)
Appearance White to off-white Solid
optical activity Consistent with structure
BRN 3604099
CAS DataBase Reference 106946-74-1(CAS DataBase Reference)
UNSPSC Code 12352108
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
NFPA 704
1
0 0

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 660205 N-Boc-(2S,3S)-(?)-2-amino-3-methyl-1-pentanol 96% 106946-74-1 10g $342 2023-06-20 Buy
Usbiological 264775 Boc-Isoleucinol Asreported 106946-74-1 1g $366 2026-06-03 Buy
Usbiological 264775 Boc-Isoleucinol Asreported 106946-74-1 2g $508 2026-06-03 Buy
Usbiological 264775 Boc-Isoleucinol Asreported 106946-74-1 5g $745 2026-06-03 Buy
Usbiological 264775 Boc-Isoleucinol Asreported 106946-74-1 10g $1028 2026-06-03 Buy
Product number Packaging Price Buy
660205 10g $342 Buy
264775 1g $366 Buy
264775 2g $508 Buy
264775 5g $745 Buy
264775 10g $1028 Buy

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Chemical Properties, Uses, Production

Chemical Properties

Colorless Liquid

Synthesis

BOC-L-Isoleucine

13139-16-7

Carbamic acid, [1-(hydroxymethyl)-2-methylbutyl]-, 1,1-dimethylethyl ester, [R-(R*,S*)]- (9CI)

141321-52-0

N-Boc-L-isoleucine (13.86 g, 60 mmol) was dissolved in THF (150 mL) under argon protection and cooled to 0°C. A 1 M BH3-THF solution (90 mL, 90 mmol) was slowly added dropwise over 20 min. After keeping 0 °C and continuing to stir for 30 min, the reaction mixture was allowed to gradually warm up to room temperature and stirred for 5 h. The reaction was then carried out at 0 °C for 5 min. Upon completion of the reaction, the mixture was again cooled to 0 °C and water was added dropwise to quench the reaction. Most of the THF was evaporated under reduced pressure and the residue was extracted by adding ethyl acetate (180 mL) and water (60 mL) to the residue. The organic layer was separated, washed sequentially with water (50 mL) and saturated brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give N-Boc-D-isoleucinol (12.89 g, 99% yield) as a colorless oil. The product could be used in the next reaction without further purification. [α]25D +14.8 (c 1.0, MeOH); 1H NMR (400 MHz, CDCl3) δ 5.04 (dd, J=48.3, 13.9 Hz, 1H), 3.73-3.55 (m, 2H), 3.48 (s, 1H), 3.37 (s, 1H), 1.58 (d, J=14.5 Hz, 1H). 1.56-1.48 (m, 1H), 1.45 (s, 9H), 1.23-1.05 (m, 1H), 0.91 (t, J=7.1 Hz, 6H); 13C NMR (100 MHz, CDCl3) δ 156.7, 79.3, 63.4, 56.8, 35.9, 28.4, 25.3, 15.5, 11.4; HRMS (ESI) m/z: [M+Na]+ calculated value C11H23NO3Na 240.1570, measured value 240.1530.

References

[1] Tetrahedron, 2017, vol. 73, # 16, p. 2255 - 2266
[2] Synthesis, 2011, # 9, p. 1375 - 1382
[3] Organic Letters, 2007, vol. 9, # 20, p. 3881 - 3884
[4] Journal of Chemical Research - Part S, 2003, # 8, p. 516 - 517
[5] Journal of Organic Chemistry, 1996, vol. 61, # 3, p. 826 - 830

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Preparation Products And Raw materials

Raw materials

BOC-L-Isoleucine Tetrahydrofuran Borane THF

Preparation Products

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Suppliers

Global Suppliers ( 156)
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
ITIC MEDCHEM(SUZHOU) CO.,LTD. 0512-68323967 18015559028 sales@iticmedchem.com China 528 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
ITIC MEDCHEM(SUZHOU) CO.,LTD. 61
Alfa Aesar 84
GL Biochem (Shanghai) Ltd 64
Capot Chemical Co., Ltd 66
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
Sichuan Kulinan Technology Co., Ltd 57
ChemPep, Inc. 57

View Latest Price from N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-L-Ile-ol pictures 2026-09-17 Boc-L-Ile-ol
106946-74-1
 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol pictures 2026-03-20 N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol
106946-74-1
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol pictures 2021-07-13 N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol
106946-74-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • Boc-L-Ile-ol pictures
  • Boc-L-Ile-ol
    106946-74-1
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Spectrum

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol(106946-74-1)1HNMR

106946-74-1 (N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol) Related Search:

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Boc-L-Ile-OL Boc-Isoleucinol≥ 98% (Assay) N-Boc-L-isoleucinol,99%e.e. BOC-L-isoleuinol N-T-BOC-L-ISOLEUCINOL N-T-BUTOXYCARBONYL-L-ISOLEUCINOL N-ALPHA-T-BOC-L-ISOLEUCINOL N-BOC-(2S,3S)-(-)-2-AMINO-3-METHYL-1-PENTANOL N-BOC-L-ISOLEUCINOL BOC-ISOLEUCINOL BOC-ILE-OL BOC-LLE-OL BOC-((2S,3S)-2-AMINO)-3-METHYL-1-PENTANOL N-Boc-L-isolucinole N-(2S)-Amino-(3S)-methyl-1-pentanol~N-(tert-Butoxycarbonyl)-L-isoleucinol n-boc-(2s)-amino-(3s)-methyl-1-pentanol NALPHA-tert-Butoxycarbonyl-L-isoleucinol N-alpha-t-Butyloxycarbonyl-L-isoleucinol tert-Butyl N-[(2S,3R)-1-hydroxy-3-methylpentan-2-yl]carbamate tert-Butyl((2S,3S)-1-hydroxy-3-methylpentan-2-yl)carbamate N-[(2S,3S)-1-hydroxy-3-methylpentan-2-yl]carbamic acid tert-butyl ester Carbamic acid, N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]-, 1,1-dimethylethyl ester N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol USP/EP/BP N-tert-Butoxycarbonyl-L-isoleucinol N-Boc-(2S,3S)-(?)-2-amino-3-methyl-1-pentanol BOC-L-ISOLEUCINOL 106946-74-1 Amino Alcohols Chiral Building Blocks Organic Building Blocks Amino Alcohols Boc-Amino acid series Amino Acids