GUANIDINOETHYL SULFONATE
- CAS No.
- 543-18-0
- Chemical Name:
- GUANIDINOETHYL SULFONATE
- Synonyms
- TAUROCYAMINE;SKL456;NSC 667063;Taurocyamin;Amidinotaurine;N-Guanyltaurine;N-Amidinotaurine;taurocyamine zwitterion;GUANIDINOETHYL SULFONATE;Guanidinoethanesulfonic Acid
- CBNumber:
- CB1741690
- Molecular Formula:
- C3H9N3O3S
- Molecular Weight:
- 167.19
- MDL Number:
- MFCD00084865
- MOL File:
- 543-18-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-{[Amino(imino)methyl]amino}ethanesulfonic acid AldrichCPR | PH017029 | 1G | $81.6 |
| Guanidinoethyl sulfonate ≥95% | 17572 | 500mg | $64 |
| Guanidinoethyl sulfonate ≥95% | 17572 | 1g | $121 |
| Guanidinoethyl sulfonate ≥95% | 17572 | 5g | $447 |
| Guanidinoethyl Sulfonate ~90% | G9027-32 | 1g | $403 |
| Melting point | 263-265°C |
|---|---|
| Density | 1.73±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated), Water (Heated) |
| form | Solid |
| pka | 1.31±0.50(Predicted) |
| color | White to Off-White |
| InChI | 1S/C3H9N3O3S/c4-3(5)6-1-2-10(7,8)9/h1-2H2,(H4,4,5,6)(H,7,8,9) |
| InChIKey | JKLRIMRKZBSSED-UHFFFAOYSA-N |
| CAS DataBase Reference | 543-18-0 |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39 |
| RIDADR | 3261 |
| WGK Germany | WGK 3 |
| HS Code | 2927000090 |
| Storage Class | 11 - Combustible Solids |
GUANIDINOETHYL SULFONATE price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH017029 | 2-{[Amino(imino)methyl]amino}ethanesulfonic acid AldrichCPR | 543-18-0 | 1G | $81.6 | 2023-06-20 | Buy |
| Cayman Chemical | 17572 | Guanidinoethyl sulfonate ≥95% | 543-18-0 | 500mg | $64 | 2026-04-30 | Buy |
| Cayman Chemical | 17572 | Guanidinoethyl sulfonate ≥95% | 543-18-0 | 1g | $121 | 2026-04-30 | Buy |
| Cayman Chemical | 17572 | Guanidinoethyl sulfonate ≥95% | 543-18-0 | 5g | $447 | 2026-04-30 | Buy |
| Usbiological | G9027-32 | Guanidinoethyl Sulfonate ~90% | 543-18-0 | 1g | $403 | 2026-06-03 | Buy |
GUANIDINOETHYL SULFONATE Chemical Properties,Uses,Production
Description
Guanidinoethyl sulfonate, also known as taurocyamine, is a natural guanidine-taurine analog derived from taurine. It is an intermediate of taurine and hypotaurine metabolism and is phosphorylated by taurocyamine kinase. Guanidinoethyl sulfonate competitively inhibits taurine uptake by sodium-dependent taurine transporters in rat hepatocytes (Ki = 1.75 mM). It also acts as a competitive glycine receptor antagonist in mouse striatal neurons. Plasma levels of guanidinoethyl sulfonate are significantly increased in patients with chronic renal failure.
Chemical Properties
White Solid
Uses
A potent inhibitor of taurine transport.
Definition
ChEBI: Zwitterionic form of taurocyamine arising from transfer of a proton from the sulfo to the guanidino group; major species at pH 7.3.
in vitro
guanidinoethyl sulphonate was found to be an analogue of taurine and an inhibitor of taurine transport. guanidinoethyl sulphonate was also shown to be a weak agonist at gaba(a) receptors, and was able to antagonize gaba-evoked responses. guanidinoethyl sulphonate did not gate glyr. 3. but antagonized glycine responses in a concentration-dependent and surmountable manner. glycine receptor-mediated taurine responses were competitively antagonized by guanidinoethyl sulphonate. taurine dose-response curves, in contrast to the glycine dose-response curves were shifted by guanidinoethyl sulphonate to the right in a parallel manner [1].
in vivo
guanidinoethyl sulphonate delivered in the drinking water of rats for 1 month could effectively reduce taurine levels in brain structures and outside the brain by between 50 and 80 %, depending on the tissue. this partial taurine depletion could not affect either basal synaptic transmission or the late phase of long-term potentiation in hippocampal slices. in-vivo microdialysis studies in the hippocampus demonstrated that guanidinoethyl sulphonate was able to reduce extracellular taurine levels and the magnitude of taurine released in response to the application of either n-methyl-d-aspartate or a hypoosmotic solution [2].
References
[1] sergeeva, o. a.,chepkova, a.n., and hass, h.l. guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. british journal of pharmacology 137, 855-860 (2002).
[2] suárez lm, muoz md, gonzález jc, bustamante j, del río rm, solís jm. the taurine transporter substrate guanidinoethyl sulfonate mimics the action of taurine on long-term synaptic potentiation. amino acids. 2016 nov;48(11):2647-2656. epub 2016 jul 15.
GUANIDINOETHYL SULFONATE Preparation Products And Raw materials
Raw materials
Preparation Products
GUANIDINOETHYL SULFONATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3861 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9930 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Shaanxi Dideu New Materials Co. Ltd | 18192503167 | 1036@dideu.com | China | 13339 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from GUANIDINOETHYL SULFONATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-21 | Guanidinoethyl sulfonate
543-18-0
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-07-14 | Guanidinoethyl sulfonate
543-18-0
|
$40.00-64.00 | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-22 | GUANIDINOETHYL SULFONATE
543-18-0
|
1KG | 99% | 10kg/100kg | Career Henan Chemica Co |
-
- Guanidinoethyl sulfonate
543-18-0
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Guanidinoethyl sulfonate
543-18-0
- $40.00-64.00
- 99.86%
- TargetMol Chemicals Inc.
-
- GUANIDINOETHYL SULFONATE
543-18-0
- $0.37
- 99%
- Career Henan Chemica Co
