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2,3,5,6-Tetrafluorophenol

2,3,5,6-Tetrafluorophenol Structure
2,3,5,6-Tetrafluorophenol structure
CAS No.
769-39-1
Chemical Name:
2,3,5,6-Tetrafluorophenol
Synonyms
Tfp-OH;Tetrafluorophenol;2,3,5,6-Tetrafluorop;2,3,5,6-Tetrafluorphenol;4H-Tetrafluorophenol 98%;2,3,5,6-tetraflourophenol;2,3,5,6-TETRAFLUOROPHENOL;2,3,5,6-Tetrafluorophenol98%;Phenol, 2,3,5,6-tetrafluoro-;4-Hydroxy-1H-perfluorobenzene
CBNumber:
CB1744646
Molecular Formula:
C6H2F4O
Molecular Weight:
166.07
MDL Number:
MFCD00002157
MOL File:
769-39-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:46:50
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2,3,5,6-Tetrafluorophenol Properties

Melting point 37-39 °C (lit.)
Boiling point 140 °C (lit.)
Density 1.4445 (estimate)
Flash point 175 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 5.46±0.20(Predicted)
form Crystalline Low Melting Solid
color White
Water Solubility Partly miscible with water.
BRN 1911548
Stability Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents.
InChI InChI=1S/C6H2F4O/c7-2-1-3(8)5(10)6(11)4(2)9/h1,11H
InChIKey PBYIIRLNRCVTMQ-UHFFFAOYSA-N
SMILES C1(O)=C(F)C(F)=CC(F)=C1F
CAS DataBase Reference 769-39-1(CAS DataBase Reference)
FDA UNII TNA118I5TG
NIST Chemistry Reference 2,3,5,6-Tetrafluorophenol(769-39-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN3261
WGK Germany  3
Hazard Note  Irritant
HazardClass  8
PackingGroup  III
HS Code  29081990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
3 0

2,3,5,6-Tetrafluorophenol price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 196789 2,3,5,6-Tetrafluorophenol 97% 769-39-1 5g $58.4 2026-04-30 Buy
Sigma-Aldrich 196789 2,3,5,6-Tetrafluorophenol 97% 769-39-1 25g $193 2026-04-30 Buy
TCI Chemical T1030 2,3,5,6-Tetrafluorophenol >98.0%(T) 769-39-1 5g $43 2026-04-30 Buy
TCI Chemical T1030 2,3,5,6-Tetrafluorophenol >98.0%(T) 769-39-1 25g $131 2026-04-30 Buy
Biosynth FT104764 2,3,5,6-tetrafluorophenol 769-39-1 5g $900 2026-06-04 Buy
Product number Packaging Price Buy
196789 5g $58.4 Buy
196789 25g $193 Buy
T1030 5g $43 Buy
T1030 25g $131 Buy
FT104764 5g $900 Buy

2,3,5,6-Tetrafluorophenol Chemical Properties,Uses,Production

Chemical Properties

white solid

Uses

2,3,5,6-Tetrafluorophenol is a reagent in the preparation of polyfluorophenyl ester-terminated homobifunctional cross-linkers to be used in protein conjugation.

Synthesis

Guanidine hydrochloride

50-01-1

(E)-1-(perfluorophenyl)-3-phenylprop-2-en-1-one

54081-33-3

trans-Cinnamic acid

140-10-3

2,3,5,6-Tetrafluorophenol

769-39-1

2-amino-4-phenyl-4,5-dihydro-1H-pyrimidin-6-one

6340-72-3

Chalcone 1d (1.0 g, 3.4 mmol) was added to a 10 mL DMF solution containing guanidine hydrochloride (0.64 g, 6.7 mmol) and sodium hydride (0.32 g, 13.4 mmol). The reaction mixture was stirred at 50 °C for 1.5 h before being cooled to room temperature and subsequently poured into ice water and extracted with ethyl acetate. Undissolved material at the phase boundary was removed by filtration, resulting in the isolation of 2-amino-6-phenyl-5,6-dihydropyrimidin-4(1H)-one (7a, 0.1 g, 16% yield). The 1H NMR data and melting point (255-257 °C; literature value 257.3 °C [19]) of this product were in agreement with those reported in the literature [19]. The extract was washed with water and dried with CaCl2 and concentrated under reduced pressure to remove the solvent, yielding 0.29 g of residue, which was analyzed by NMR and GC/MS.

References

[1] Russian Journal of Organic Chemistry, 2015, vol. 51, # 12, p. 1745 - 1752
[2] Zh. Org. Khim., 2015, vol. 51, # 12, p. 1778 - 1785,8

2,3,5,6-Tetrafluorophenol synthesis

602-94-8
769-39-1
Synthesis of 2,3,5,6-Tetrafluorophenol from Pentafluorobenzoic acid

2,3,5,6-Tetrafluorophenol Preparation Products And Raw materials

Raw materials

Benzenemethanol, 2,3,5,6-tetrafluoro-4-hydroxy- Potassium pentafluorophenolate 2-(2,3,4,5,6-Pentafluoroanilino)-1-ethanol Pentafluorophenol Perfluorocyclohexane
2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid 4-Nitrophenyl acetate 2,3,4,5,6-Pentafluoroaniline Pentafluorobenzoic acid 4-Nitrophenol
Pentafluorobenzene Hypophosphorous acid

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Preparation Products

4-Bromotetrafluorophenol 2,3,5,6-Tetrafluoronitrobenzene trans-Cinnamic acid Pentanoic acid, 4-oxo-3-[[(2S)-1-oxo-2-[[(phenylMethoxy)carbonyl]aMino]propyl]aMino]-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-

2,3,5,6-Tetrafluorophenol Suppliers

Global( 294)Suppliers
Supplier Tel Email Country ProdList Advantage
Qi-Chem Co., Ltd. 0411-88165951 13601035838 marketing@qi-chem.com China 167 58
Shandong Dexin Fine Chemical Co., Ltd. 18553366272 3091507995@qq.com China 278 58
Taizhou Xinhongchuan New Material Co., Ltd 18651157028 18651157028 2579548755@qq.com China 1365 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Qi-Chem Co., Ltd. 58
Shandong Dexin Fine Chemical Co., Ltd. 58
Taizhou Xinhongchuan New Material Co., Ltd 58
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Wuhan Chemwish Technology Co., Ltd 56

View Lastest Price from 2,3,5,6-Tetrafluorophenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3,5,6-Tetrafluorophenol pictures 2026-09-14 2,3,5,6-Tetrafluorophenol
769-39-1
 $5.00 1kg ≥99% 100mt/year Jinan Finer Chemical Co., Ltd
2,3,5,6-Tetrafluorophenol pictures 2026-09-02 2,3,5,6-Tetrafluorophenol
769-39-1
 $1.20-35.00 1kg 99% Henan Fengda Chemical Co., Ltd
2,3,5,6-Tetrafluorophenol pictures 2026-06-30 2,3,5,6-Tetrafluorophenol
769-39-1
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd

2,3,5,6-Tetrafluorophenol Spectrum

2,3,5,6-Tetrafluorophenol(769-39-1)MS2,3,5,6-Tetrafluorophenol(769-39-1)1HNMR2,3,5,6-Tetrafluorophenol(769-39-1)13CNMR2,3,5,6-Tetrafluorophenol(769-39-1)IR12,3,5,6-Tetrafluorophenol(769-39-1)Raman

769-39-1(2,3,5,6-Tetrafluorophenol)Related Search:

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2,3,5,6-Tetrafluorop 2,3,5,6-tetrafluoroethane phenol 4-Hydroxy-1H-perfluorobenzene 2,3,5,6-Tetrafluorophenol, 98% 5GR 2,3,5,6-Tetrafluorophenol,tech. 2,3,5,6-Tetrafluorophenol 98% 2,3,5,6-Tetrafluorophenol98% Tfp-OH (Tetramethylfluoroformamidiniun hexafluorophosphate) 2,3,5,6-Tetrafluorophenol, min. 98% 2,3,5,6-tetraflourophenol 2,3,5,6-Tetrafluorphenol Tetrafluorophenol 4H-Tetrafluorophenol 98% 2,3,5,6-TETRAFLUOROPHENOL Phenol, 2,3,5,6-tetrafluoro- Tetrafluorophenolminwhitewaxysolid 2,3,5,6-Tetrafluorophenol, 97+% 2,3,5,6-TETRAFLUOROPHENOL 769-39-1 2,3,5,6-Tetrafluorophenol ISO 9001：2015 REACH Tfp-OH 769-39-1 F4C6HOH HC6F4OH C6H2F4O Building Blocks Oxygen Compounds Phenols Organic Building Blocks pharmacetical Phenol&Thiophenol&Mercaptan Organic Building Blocks Oxygen Compounds Phenols