alpha-Cyclopentylmandelic acid
- CAS No.
- 427-49-6
- Chemical Name:
- alpha-Cyclopentylmandelic acid
- Synonyms
- 2-Cyclopentyl-2-hydroxy-2-phenylacetic acid;CYCLOPENTYL MANDELIC ACID;Glycopyrronium Bromide EP Impurity J;α-Cyclopentylmandelic acid;Mandelic acid, alpha-cyclopentyl;Glycopyrrolate Related CoMpound C;CM ACID;pha-CycL;TIMTEC-BB SBB010054;Glycopyrronium impurity 4
- CBNumber:
- CB1751794
- Molecular Formula:
- C13H16O3
- Molecular Weight:
- 220.27
- MDL Number:
- MFCD00019296
- MOL File:
- 427-49-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 144-150 °C |
|---|---|
| Boiling point | 110 °C (0.5 mmHg) |
| Density | 1.247±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 3.53±0.25(Predicted) |
| form | Solid |
| color | White to pale brown |
| InChI | InChI=1S/C13H16O3/c14-12(15)13(16,11-8-4-5-9-11)10-6-2-1-3-7-10/h1-3,6-7,11,16H,4-5,8-9H2,(H,14,15) |
| InChIKey | WFLUEQCOAQCQLP-UHFFFAOYSA-N |
| SMILES | C(C1CCCC1)(C1C=CC=CC=1)(O)C(=O)O |
| LogP | 2.770 (est) |
| CAS DataBase Reference | 427-49-6(CAS DataBase Reference) |
| FDA UNII | XY6HY5ZM28 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-41-37/38 | |||||||||
| Safety Statements | 45-36/37/39-26-39 | |||||||||
| RIDADR | 3261 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
alpha-Cyclopentylmandelic acid price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2467 | Glycopyrrolate Related Compound C pharmaceutical secondary standard | 427-49-6 | 50MG | $833 | 2026-04-30 | Buy |
| Sigma-Aldrich | 706396 | α-Cyclopentylmandelic acid 97% | 427-49-6 | 5g | $70.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1296042 | Glycopyrrolate Related Compound C United States Pharmacopeia (USP) Reference Standard | 427-49-6 | 25mg | $1460 | 2026-04-30 | Buy |
| TCI Chemical | C2394 | alpha-Cyclopentyl-DL-mandelic Acid >98.0%(HPLC)(T) | 427-49-6 | 5g | $40 | 2026-04-30 | Buy |
| TCI Chemical | C2394 | alpha-Cyclopentyl-DL-mandelic Acid >98.0%(HPLC)(T) | 427-49-6 | 25g | $177 | 2026-04-30 | Buy |
alpha-Cyclopentylmandelic acid Chemical Properties, Uses, Production
Chemical Properties
white to beige powder
Uses
intermediate for Glycopyrronium Bromide, Oxyphencyclimine HCl, Oxypyrronium Bromide
Uses
2-Cyclopentyl-2-hydroxy-2-phenylacetic Acid is an impurity of Glycopyrrolate (G657000), a novel pharmaceutical compound based on PDE IV inhibitors; used in the treatment of respiratory complaints. It is used in the synthesis of muscarinic M3 receptor antagonists.
Research
Resolving racemic alpha-cyclopentylmandelic acid by a chemical resolution method by using L-Tyrosine methyl ester and (R)-alpha-phenylethylamine as resolution reagents to respectively prepare (S)-alpha-cyclopentylmandelic acid and (R)-alpha-cyclopentylmandelic acid; and carrying out esterification reaction to respectively obtain chiral intermediates (S)/(R)-alpha-cyclopentylmethyl mandelate. Multistage enantioselective liquid-liquid extraction (ELLE) of α--cyclopentyl-mandelic acid (α-CPMA) enantiomers using hydroxyethyl-β-cyclodextrin (HE-β-CD) as extractant was studied in a cascade of centrifugal contactor separators (CCSs)[1].
References
[1] Panliang Zhang. “Study on enantioseparation of α-cyclopentyl-mandelic acid enantiomers using continuous liquid-liquid extraction in centrifugal contactor separators: Experiments and modeling.” Chemical Engineering and Processing - Process Intensification 107 (2016): Pages 168-176.
alpha-Cyclopentylmandelic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| Shengbaolai Biotechnology Co., Ltd | 027-86-027-59105235 15527244834 | shengblai@126.com | China | 489 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Latest Price from alpha-Cyclopentylmandelic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | alpha-Cyclopentylmandelic acid
427-49-6
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2026-08-21 | alpha-Cyclopentylmandelic acid
427-49-6
|
$955.00-970.00 | 1kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD | |
 |
2026-08-07 | alpha-Cyclopentylmandelic acid
427-49-6
|
1KG | 98% | 10KG | Shaanxi Dideu Medichem Co. Ltd |
-
- alpha-Cyclopentylmandelic acid
427-49-6
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- alpha-Cyclopentylmandelic acid
427-49-6
- $955.00-970.00
- 99.99%
- Hebei Dangtong Import and export Co LTD
-
- alpha-Cyclopentylmandelic acid
427-49-6
- 98%
- Shaanxi Dideu Medichem Co. Ltd
