L-701,324
- CAS No.
- 142326-59-8
- Chemical Name:
- L-701,324
- Synonyms
- L-701;CS-2045;L-701,324;L-701,304;L-701324, 10 mM in DMSO;L 701324, glycine site NMDA receptor antagonist;7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)-quinolinone;7-CHLORO-4-HYDROXY-3-(3-PHENOXY)PHENYL-2(1H)-QUINOLINONE;7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one;7-chloro-1-(4-hydroxy-3-phenoxyphenyl)quinolin-2(1H)-one
- CBNumber:
- CB1757589
- Molecular Formula:
- C21H14ClNO3
- Molecular Weight:
- 363.79
- MDL Number:
- MFCD00910917
- MOL File:
- 142326-59-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 308 °C |
|---|---|
| Boiling point | 584.7±50.0 °C(Predicted) |
| Density | 1.389±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: soluble36.4mg/mL |
| form | solid |
| pka | 4.50±1.00(Predicted) |
| color | White to off-white |
| FDA UNII | I9WY146163 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
L-701,324 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30687 | L-701,324 ≥98% | 142326-59-8 | 10mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 30687 | L-701,324 ≥98% | 142326-59-8 | 50mg | $378 | 2026-04-30 | Buy |
| Cayman Chemical | 30687 | L-701,324 ≥98% | 142326-59-8 | 100mg | $553 | 2026-04-30 | Buy |
| Usbiological | 217500 | L-701,324 (7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone) ~98%(HPLC) | 142326-59-8 | 10mg | $452 | 2026-06-03 | Buy |
| Biosynth | SFA32659 | L-701,324 | 142326-59-8 | 50mg | $787 | 2026-06-05 | Buy |
L-701,324 Chemical Properties, Uses, Production
Uses
L-701,324 is a potential anticonvulsant with high selectivity and affinity for the NMDA receptor glycine site. NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment.
Definition
ChEBI: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one is a member of quinolines.
Biological Activity
An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
in vivo
L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice[1].
L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus[1].
L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations[2].
| Animal Model: | Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) [1] |
| Dosage: | 5 and 10 mg/kg |
| Administration: | Intraperitoneal injection; daily, for 2 weeks |
| Result: | Reduced the immobility of C57BL/6 J mice. Increased the expression of BDNF, pTrkB and pCREB in the hippocampus. |
| Animal Model: | Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)[1] |
| Dosage: | 5 and 10 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Reduced the immobility of C57BL/6 J mice in the FST and TST. |
| Animal Model: | Male Sprague-Dawley rats (280-300 g)[2] |
| Dosage: | 2.5 and 5 mg/kg |
| Administration: | Oral administration; once |
| Result: | Increased in the percentage of time spent in the open arm in a dose-dependent. Increased punished responding in the Vogel's conflict test in a dose-dependent fashion. |
IC 50
NMDA Receptor
storage
Store at RT
L-701,324 Preparation Products And Raw materials
Raw materials
Preparation Products
L-701,324 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Zhengzhou Saifun Biotechnology Co., Ltd. | 022-60688926 | China | 60 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
