2,2-Bis(hydroxymethyl)propionic acid
- CAS No.
- 4767-03-7
- Chemical Name:
- 2,2-Bis(hydroxymethyl)propionic acid
- Synonyms
- DMPA;DIMETHYLOLPROPIONIC ACID;3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid;Bis-MPA;Bis(hydroxymethyl)propionic acid;DiMethylol Propionic;2,2-DIMETHYLOLPROPIONIC ACID;2,2-Bis(methylol)propionic acid;2,2-bis(hydroxymethyl)propanoicacid;Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-
- CBNumber:
- CB1759235
- Molecular Formula:
- C5H10O4
- Molecular Weight:
- 134.13
- MDL Number:
- MFCD00004199
- MOL File:
- 4767-03-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 189-191 °C(lit.) |
|---|---|
| Boiling point | 167.23°C (rough estimate) |
| Density | 0.84 |
| vapor density | <1 (vs air) |
| refractive index | 1.4240 (estimate) |
| Flash point | >150°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble |
| pka | 4.16±0.15(Predicted) |
| form | Crystalline Powder |
| color | White |
| PH | 2.6 (50g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,3253 |
| BRN | 1756385 |
| Stability | Stable. Hygroscopic. |
| InChI | 1S/C5H10O4/c1-5(2-6,3-7)4(8)9/h6-7H,2-3H2,1H3,(H,8,9) |
| InChIKey | PTBDIHRZYDMNKB-UHFFFAOYSA-N |
| SMILES | CC(CO)(CO)C(O)=O |
| Indirect Additives used in Food Contact Substances | DIMETHYLOLPROPIONIC ACID |
| FDA 21 CFR | 175.105; 176.170; 178.3725 |
| CAS DataBase Reference | 4767-03-7(CAS DataBase Reference) |
| FDA UNII | 4NHI8V17MN |
| NIST Chemistry Reference | 2,2-Bis(hydroxymethyl)propionic acid(4767-03-7) |
| EPA Substance Registry System | Dimethylolpropionic acid (4767-03-7) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36/37 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UA2465265 | |||||||||
| F | 3-9 | |||||||||
| Autoignition Temperature | >300 °C | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29159000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,2-Bis(hydroxymethyl)propionic acid price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.14996 | 2,2-Bis(hydroxymethyl)propionic acid for synthesis | 4767-03-7 | 250g | $88.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.14996 | 2,2-Bis(hydroxymethyl)propionic acid for synthesis | 4767-03-7 | 1kg | $224 | 2026-04-30 | Buy |
| Sigma-Aldrich | 106615 | 2,2-Bis(hydroxymethyl)propionic acid 98% | 4767-03-7 | 3kg | $209 | 2026-04-30 | Buy |
| Sigma-Aldrich | 106615 | 2,2-Bis(hydroxymethyl)propionic acid 98% | 4767-03-7 | 12kg | $576 | 2026-04-30 | Buy |
| TCI Chemical | B1192 | 2,2-Bis(hydroxymethyl)propionic Acid >97.0%(T) | 4767-03-7 | 25g | $19 | 2026-04-30 | Buy |
2,2-Bis(hydroxymethyl)propionic acid Chemical Properties, Uses, Production
Chemical Properties
white crystalline powder
Uses
2,2-bis(hydroxymethyl)propionic acid (DMPA) is a versatile organic materials. it is used as water-based polyurethane chain extender, also make the polyurethane obtained from emulsifying properties, excellent stability can be made self-emulsifying aqueous polyurethane. For preparation a photosensitive resin and liquid crystal materials; for epoxy ester coatings, polyurethane elastomers and powder coatings; Preparation of magnetic recording materials and adhesives etc..
Uses
In preparation of water-sol alkyl resins.
Uses
2,2-Bis(hydroxymethyl)propionic acid is commonly used as an AB2 monomer for the synthesis of hyperbranched (hb) polymers and dendrimers.
Definition
ChEBI: 2,2-Bis(hydroxymethyl)propionic acid is a 3-hydroxy carboxylic acid.
Synthesis
2,2-dihydroxypropionic acid preparation method steps are as follows:
Add 980Kg of pure water in 3000L reactor, put 16Kg of activated carbon loaded sodium hydroxide, add 1000Kg of formaldehyde, drop 300Kg of n-propanal, drop finished for 20-60 constant temperature 6-14h;
Add 10Kg of formic acid to neutralize the pH value between 6 and 7.2;
Transfer to oxidizing kettle, concentrate in oxidizing kettle under reduced pressure, recover part of unreacted formaldehyde;
Add 580Kg of hydrogen peroxide at elevated temperature, and carry out constant temperature of 60-90 for 6-10h after dropping;
Add 400Kg to 800Kg of water, and concentrate under reduced pressure;
Concentrate to water between 5—8%, cool and crystallize, centrifuge to get 2,2-dihydroxymethylpropionic acid crude product. The mother liquor was filtered for recirculation recrystallization;
Add 1000kg of water to 1000kg of crude product, warm it up to 50-60 with stirring, add a small amount of iron remover and about 5kg of activated carbon, and filter it after half an hour to remove the activated carbon. Concentrate again at atmospheric pressure to the water content between 25wt%~30wt% discharge cooling crystallization, and then centrifugation, drying and sieving and other treatments to get 2,2-dihydroxymethylpropionic acid product.
The crude mother liquor is re-concentrated and then recrystallized to extract the product again; the fine mother liquor is then concentrated, decolorized, crystallized, centrifuged and dried to recover the product again. The refined mother liquor is recycled and returned as crude mother liquor. The crude mother liquor after extracting products again is finally treated as waste water. The mother liquor after each filtration was well treated to recover 2,2-dihydroxymethylbutyric acid in the mother liquor and improve the product yield.
2,2-Bis(hydroxymethyl)propionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai ideal Industrial Co., Ltd. | 021-58957966 18930537195 | wouchina@126.com | China | 3021 | 58 |
| Guangzhou Rui Lion Biotechnology Co., LTD | 13168345686 17306666488 | 607141423@qq.com | China | 1725 | 58 |
| Zhengzhou HongSheng Pharmaceutical Co., Ltd. | 0371-0371-13526885213 15637198702 | hsyykjchem@163.com | China | 1857 | 58 |
| Shandong Mingde Biotechnology Co., Ltd | 15564477061 | 1397986535@qq.com | China | 272 | 58 |
| Henan Yingchuang Chemical Co., Ltd. | 18260259434 | 3591654775@qq.com | China | 320 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
View Latest Price from 2,2-Bis(hydroxymethyl)propionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 2,2-Dimethylolpropionic Acid
4767-03-7
|
$28.00 | 300kg | ≥99% Industrial Grade | 20 tons | Nexal Inc | |
 |
2026-07-03 | 2,2-Bis(hydroxymethyl)propionic acid
4767-03-7
|
1g | 98% | 1000g | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 2, 2-Bis (hydroxymethyl) Propionic Acid
4767-03-7
|
10KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2,2-Dimethylolpropionic Acid
4767-03-7
- $28.00
- ≥99% Industrial Grade
- Nexal Inc
-
- 2,2-Bis(hydroxymethyl)propionic acid
4767-03-7
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2, 2-Bis (hydroxymethyl) Propionic Acid
4767-03-7
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
2,2-Bis(hydroxymethyl)propionic acid Spectrum
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