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Dibenzyl diisopropylphosphoramidite

Dibenzyl diisopropylphosphoramidite structure

CAS No.: 108549-23-1

Chemical Name:: Dibenzyl diisopropylphosphoramidite

Synonyms: DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE;DIBENZYL N,N-DIISOPRO;Dibenzyl-N,N-disisopropylphosphoramidite;LABOTEST-BB LT00451623;108549-23-1,108549-23-1;Dibenzyl diisopropylphosphoramidite;Dibenzyl diisopropylphosphoramidoite;Dibenyl NN diisopropylphosphoramidite;DIBENZYLOXY(DIISOPROPYLAMINO)PHOSPHINE;DIBENZYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE

CBNumber:: CB1772267

Molecular Formula:: C20H28NO2P

Molecular Weight:: 345.42

MDL Number:: MFCD00191988

MOL File:: 108549-23-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:50:05

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Dibenzyl diisopropylphosphoramidite Properties

Boiling point	130 °C0.55 mm Hg(lit.)
Density	1.028 g/mL at 25 °C(lit.)
refractive index	n20/D 1.535(lit.)
Flash point	158 °F
storage temp.	2-8°C
solubility	Soluble in chloroform.
pka	4.50±0.70(Predicted)
form	Oil
color	Clear Colourless
Water Solubility	THF: soluble(lit.) acetonitrile: soluble(lit.) cold water: insoluble(lit.) dichloromethane: soluble(lit.)
Sensitive	Moisture Sensitive
BRN	3616864
InChI	InChI=1S/C20H28NO2P/c1-17(2)21(18(3)4)24(22-15-19-11-7-5-8-12-19)23-16-20-13-9-6-10-14-20/h5-14,17-18H,15-16H2,1-4H3
InChIKey	ANPWLBTUUNFQIO-UHFFFAOYSA-N
SMILES	P(N(C(C)C)C(C)C)(OCC1=CC=CC=C1)OCC1=CC=CC=C1
CAS DataBase Reference	108549-23-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227-H315-H319-H335

Precautionary statements

P210e-P261-P280a-P305+P351+P338-P405-P501a-P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

3-10-21

HS Code

29319090

Storage Class

10 - Combustible liquids

NFPA 704

	2
2		1

Dibenzyl diisopropylphosphoramidite price More Price(82)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	416436	Dibenzyl N,N-diisopropylphosphoramidite technical grade, 90%	108549-23-1	5ml	$123	2026-04-30	Buy
Sigma-Aldrich	416436	Dibenzyl N,N-diisopropylphosphoramidite technical grade, 90%	108549-23-1	25ml	$400	2026-04-30	Buy
TCI Chemical	D2624	Dibenzyl N,N-Diisopropylphosphoramidite >98.0%(T)	108549-23-1	5g	$190	2026-04-30	Buy
Usbiological	270709	Dibenzyl N,N-diisopropylphosphoramidite Asreported	108549-23-1	1g	$319	2026-06-03	Buy
Usbiological	270709	Dibenzyl N,N-diisopropylphosphoramidite Asreported	108549-23-1	2g	$432	2026-06-03	Buy

Product number	Packaging	Price	Buy
416436	5ml	$123	Buy
416436	25ml	$400	Buy
D2624	5g	$190	Buy
270709	1g	$319	Buy
270709	2g	$432	Buy

Dibenzyl diisopropylphosphoramidite Chemical Properties, Uses, Production

Description

Dibenzyl diisopropylphosphoramidite is a versatile phosphitylating agent.

Chemical Properties

Clear Colourless Liquid

Uses

A versatile phosphitylating agent

Uses

Dibenzyl N,N-diisopropylphosphoramidite may be used for the preparation of phosphopeptides. It is used for the synthesis of a GDP (guanosine diphosphate) analog, SML-8-73-1. It is useful for nucleotide coupling.

Synthesis

921-26-6

100-51-6

108549-23-1

General procedure for the synthesis of diphenyl N,N'-diisopropylphosphoramidite from dichloro-N,N-diisopropylphosphoramidite and benzyl alcohol: 42 g (207.92 mmol) of dichloro-N,N-diisopropylphosphoramidite was placed in a 500 mL round-bottomed flask, and 300 mL of anhydrous tetrahydrofuran was added, and dissolved by stirring. Subsequently 66 mL (455.44 mmol, 46 g) of anhydrous triethylamine was added. The flask was cooled to 0°C in an ice-salt bath and 45 mL (416.67 mmol, 45 g) of anhydrous benzyl alcohol was added slowly and dropwise under nitrogen protection, keeping the reaction temperature close to 0°C. Upon completion of the reaction, the suspension was added dropwise and the formation of a white solid was observed. The reaction mixture was removed from the ice bath, returned to room temperature and stirring was continued for 3 hours. After stopping stirring, it was allowed to stand for 10 minutes for filtration and the solid was washed with tetrahydrofuran. The filtrate was collected and the solvent was removed by rotary evaporation to give the crude product. Without column chromatographic purification, 54.0 g of the oily product was obtained directly in 75.3% yield.

References

[1] Tetrahedron, 1991, vol. 47, # 26, p. 4709 - 4722
[2] Patent: CN102977145, 2017, B. Location in patent: Paragraph 0196; 0197
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 11, p. 1239 - 1246
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 23, p. 3918 - 3927
[5] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7719 - 7726

Dibenzyl diisopropylphosphoramidite synthesis

Synthesis of Dibenzyl diisopropylphosphoramidite from Diisopropylphosphoramidous dichloride and Benzyl alcohol

Dibenzyl diisopropylphosphoramidite Preparation Products And Raw materials

Raw materials

Benzyl alcohol Toluene Triethylamine Diisopropylamine Phosphorus trichloride

Tetrahydrofuran Ethyl acetate Dichloromethane Diisopropylphosphoramidous dichloride

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Preparation Products

D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,5,6-tris-O-(phenylmethyl)-, bisbis(phenylmethyl) phosphate dibenzyl (2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-yl) phosphate

Dibenzyl diisopropylphosphoramidite Suppliers

Global Suppliers ( 252)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	472	75
Xinxiang Runyu Material Co., Ltd.	166-166-37336996 15690792173	chenxi.song@runvmat.com	China	282	55
Hangzhou Benoy Chemical Co., Ltd.	17342059697	sales@benoychem.com	China	209	58
Wuhan Boye Technology Development Co., Ltd.	027-81625225 15377010747	hui@boyechemicals.com	China	493	58
Jiangxi Boye Medical Technology Co., Ltd	027-18971341812/18971341812 18971341812	anikay@boyechemicals.com	China	480	58
Jiangxi Boye Medical Technology Co., Ltd	15387090420 15387090420;	2684361091@qq.com	China	468	58
Hangzhou Aolishen Chemical Co., Ltd.	571-81727727 15267468089	Frank.luo@aolisenchemical.com	China	473	58
Nantong Subei Chemical Raw Materials Co., Ltd.	0513-85290972 18762756250	ntsbhg@163.com	China	9277	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62

Supplier	Advantage
Suzhou Highfine Biotech Co., Ltd	75
Xinxiang Runyu Material Co., Ltd.	55
Hangzhou Benoy Chemical Co., Ltd.	58
Wuhan Boye Technology Development Co., Ltd.	58
Jiangxi Boye Medical Technology Co., Ltd	58
Jiangxi Boye Medical Technology Co., Ltd	58
Hangzhou Aolishen Chemical Co., Ltd.	58
Nantong Subei Chemical Raw Materials Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62

View Latest Price from Dibenzyl diisopropylphosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	Dibenzyl diisopropylphosphoramidite 108549-23-1	$99.00	1Kg	99%	20Ton	Xinxiang Aurora Biotechnology Co.,Ltd.
2025-12-23	DIBENZYL DIISOPROPYLPHOSPHORAMIDITE 108549-23-1		1g	99%+	1000kg	XINXIANG RUNYU MATERIAL CO., LTD.
2025-06-27	Dibenzyl diisopropylphosphoramidite 108549-23-1		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

Dibenzyl diisopropylphosphoramidite
108549-23-1
$99.00
99%
Xinxiang Aurora Biotechnology Co.,Ltd.

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE
108549-23-1
99%+
XINXIANG RUNYU MATERIAL CO., LTD.

Dibenzyl diisopropylphosphoramidite
108549-23-1
99%
Hebei Chuanghai Biotechnology Co., Ltd

Dibenzyl diisopropylphosphoramidite Spectrum

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE(108549-23-1)¹HNMR DIBENZYL DIISOPROPYLPHOSPHORAMIDITE(108549-23-1)FT-IR DIBENZYL DIISOPROPYLPHOSPHORAMIDITE(108549-23-1)IR

108549-23-1 (Dibenzyl diisopropylphosphoramidite) Related Search:

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Dibenzyl diisopropylphosphoramidite Bis[1-(2-nitrophenyl)ethyl] N,N-diisopropylphosphoramidite Dibenzyl diethylphosphoramidite Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite

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N-[bis(phenylmethoxy)phosphanyl]-N-propan-2-yl-propan-2-amine N-[bis(phenylmethoxy)phosphanyl]-N-propan-2-ylpropan-2-amine Dibenzyl-N,N-disisopropylphosphoramidite Dibenzyl N,N-diisopropylphosphoramidite, 95+% Dibenzyl N,N-diisopropylphosphoramidite, tech 90% DIBENZYL N,N-DIISOPRO DIBENZYLOXY(DIISOPROPYLAMINO)PHOSPHINE DIBENZYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE LABOTEST-BB LT00451623 bis(benzyloxy)(diisopropylamino)phosphine β-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite PHOSPHORAMIDOUS ACID, N,N-BIS(1-METHYLETHYL)-, BIS(PHENYLMETHYL) ESTER DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE, TECHNICAL GRADE, 90% Dibenzyl N,N-diisopropylphosphoramidite,90+% N,N-Bis(1-methylethyl)phosphoramidous acid bis(phenylmethyl) ester bis(benzyloxy)phosphino-diisopropyl-amine Dibenzyl diisopropylphosphoramidite, 90%, for synthesis DibenzylN,N-Diisopropylphosphoramidite> Dibenzyl N,N-Diisopropylphosphoramidite,98% Dibenyl NN diisopropylphosphoramidite DIBENZYL DIISOPROPYLPHOSPHORAMIDITE USP/EP/BP 108549-23-1,108549-23-1 Dibenzyl diisopropylphosphoramidoite Dibenzyl N,N-diisopropylphosphoramidite DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE Dibenzyl diisopropylphosphoramidite 108549-23-1 08549-23-1 C20H28NO2P CH32CH2NPOCH2C6H52 Building Blocks Phosphorylation DNA / RNA Synthesis Phosphorylating Agents Organic Building Blocks Phosphoramidites Phosphorus Compounds OLED materials,pharm chemical,electronic Organic Building Blocks Phosphoramidites Phosphorus Compounds Phospholipids - 13C & 2H Biochemistry Nucleosides, Nucleotides & Related Reagents Phosphorylating and Phosphorothioating Agents Phosphorylation Protecting Agents, Phosphorylating Agents & Condensing Agents Synthetic Organic Chemistry Phosphorylating and Phosphitylating Agents SiChem OLED