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ChemicalBook >> CAS DataBase List >>2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide

2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide

2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide Structure
2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide structure
CAS No.
568544-03-6
Chemical Name:
2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide
Synonyms
GSTO1-IN-1;GSTO1 inhibitor 1;GSTO1-IN-1, 10 mM in DMSO;2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide;2-Chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acetamide;2-Chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]acetamide;Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]-;GSTs,GSTO1IN1,Glutathione transferases,inhibit,Inhibitor,Gutathione S-transferase,GSTO1 IN 1,GSTO-1-IN-1
CBNumber:
CB1774579
Molecular Formula:
C10H12Cl2N2O3S
Molecular Weight:
311.18
MDL Number:
MFCD03965279
MOL File:
Mol file
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:05
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2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide Properties

storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501

2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0042397 GSTO1-IN-1 99.11% 568544-03-6 5mg $104 2026-06-04 Buy
ChemScene CS-0042397 GSTO1-IN-1 99.11% 568544-03-6 10mg $162 2026-06-04 Buy
ChemScene CS-0042397 GSTO1-IN-1 99.11% 568544-03-6 50mg $238 2026-06-04 Buy
ChemScene CS-0042397 GSTO1-IN-1 99.11% 568544-03-6 100mg $412 2026-06-04 Buy
aablocks AA00ECLZ 2-Chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acetamide ≥95% 568544-03-6 1mg $22 2026-05-28 Buy
Product number Packaging Price Buy
CS-0042397 5mg $104 Buy
CS-0042397 10mg $162 Buy
CS-0042397 50mg $238 Buy
CS-0042397 100mg $412 Buy
AA00ECLZ 1mg $22 Buy

2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide Chemical Properties, Uses, Production

Uses

GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with an IC50 of 31 nM.

Biological Activity

GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM.

in vitro

GSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC 50 value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations.

in vivo

To test whether GSTO1-IN-1 had in vivo efficacy, its effects are evaluated in a human colon cancer cell line xenograft model. GSTO1-IN-1 (20-45 mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment is generally well tolerated by mice up to 45 mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study[1].

target

IC50: 31 nM (GSTO1)

References

[1] Ramkumar K, et al. Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor. Nat Commun. 2016 Oct 5;7:13084. DOI:10.1038/ncomms13084

2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide Suppliers

Global Suppliers ( 37)
Supplier Tel Email Country ProdList Advantage
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-85201366 18938635012 sales@regentsciences.com China 9384 58
Twochem Co.Ltd. 021-58111628 15800915896 sales@twochem.com China 1782 58
Jiangsu aikang biomedical research and development co., LTD 025-58859352 17714375163 qzhang@aikonchem.com China 15525 58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd. 18081075745 chemflowtech@sina.com China 1883 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Supplier Advantage
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shenzhen Regent Biochemical Technology Co., Ltd. 58
Twochem Co.Ltd. 58
Jiangsu aikang biomedical research and development co., LTD 58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
InvivoChem 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58

View Latest Price from 2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSTO1-IN-1 pictures 2026-07-27 GSTO1-IN-1
568544-03-6
 $30.00-73.00 98.11% 10g TargetMol Chemicals Inc.
GSTO1-IN-1 pictures 2026-07-27 GSTO1-IN-1
568544-03-6
 $30.00-73.00 98.11% 10g TargetMol Chemicals Inc.
  • GSTO1-IN-1 pictures
  • GSTO1-IN-1
    568544-03-6
  • $30.00-73.00
  • 98.11%
  • TargetMol Chemicals Inc.
  • GSTO1-IN-1 pictures
  • GSTO1-IN-1
    568544-03-6
  • $30.00-73.00
  • 98.11%
  • TargetMol Chemicals Inc.

2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide Spectrum

2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE(568544-03-6)1HNMR

568544-03-6 (2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide) Related Search:

2-Chloro-N-[3-(methyl-phenyl-sulfamoyl)-phenyl]-acetamide 2-Chloro-N-(3-dimethylsulfamoyl-4-methyl-phenyl)-acetamide Acetamide, 2-chloro-N-[2-chloro-5-[(diethylamino)sulfonyl]phenyl]- Acetamide, 2-chloro-N-[3-[(diethylamino)sulfonyl]phenyl]- N-[5-(Azepane-1-sulfonyl)-2-chloro-phenyl]-2-chloro-acetamide
2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide

1of2

GSTO1-IN-1 GSTO1 inhibitor 1 Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]- 2-Chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acetamide 2-Chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]acetamide GSTs,GSTO1IN1,Glutathione transferases,inhibit,Inhibitor,Gutathione S-transferase,GSTO1 IN 1,GSTO-1-IN-1 GSTO1-IN-1, 10 mM in DMSO 2-Chloro-N-(4-chloro-3-dimethylsulfamoyl-phenyl)-acetamide 568544-03-6