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(Rac)-AMG8380

(Rac)-AMG8380 Structure
(Rac)-AMG8380 structure
CAS No.
1641574-26-6
Chemical Name:
(Rac)-AMG8380
Synonyms
(Rac)-AMG8380;(Rac)-AMG8379;(Rac)-AMG8379/(Rac)-AMG8380;(Rac)-AMG8379, 10 mM in DMSO;6-Quinolinesulfonamide, 1-(3'-chloro-2,5'-difluoro-5-methoxy[1,1'-biphenyl]-4-yl)-1,2-dihydro-N-3-isoxazolyl-2-oxo-
CBNumber:
CB18054510
Molecular Formula:
C25H16ClF2N3O5S
Molecular Weight:
543.93
MDL Number:
MOL File:
1641574-26-6.mol
Last updated:2025-09-20 20:09:13
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(Rac)-AMG8380 Properties

Boiling point 752.0±70.0 °C(Predicted)
Density 1.527±0.06 g/cm3(Predicted)
pka 4.89±0.20(Predicted)

(Rac)-AMG8380 Chemical Properties,Uses,Production

Uses

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].

IC 50

hNav1.7: 8.5 nM (IC50); mNav1.7: 18.6 nM (IC50)

References

[1] Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160. DOI:10.1124/jpet.116.239590

(Rac)-AMG8380 Preparation Products And Raw materials

Raw materials

Preparation Products

(Rac)-AMG8380 Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 18100677375 sales@szzxbio.com China 3000 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5840 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29545 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Guangzhou Taozhu Biotechnology Co., Ltd 4008200310 CHINA 111 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
Guangzhou Taozhu Biotechnology Co., Ltd 58

View Lastest Price from (Rac)-AMG8380 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(Rac)-AMG8379 pictures 2025-09-19 (Rac)-AMG8379
1641574-26-6
 US $195.00-658.00 / mg 99.90% 10g TargetMol Chemicals Inc.
(Rac)-AMG8379 pictures 2025-09-19 (Rac)-AMG8379
1641574-26-6
 US $195.00-658.00 / mg 99.90% 10g TargetMol Chemicals Inc.
  • (Rac)-AMG8379 pictures
  • (Rac)-AMG8379
    1641574-26-6
  • US $195.00-658.00 / mg
  • 99.90%
  • TargetMol Chemicals Inc.
  • (Rac)-AMG8379 pictures
  • (Rac)-AMG8379
    1641574-26-6
  • US $195.00-658.00 / mg
  • 99.90%
  • TargetMol Chemicals Inc.

(Rac)-AMG8380 Spectrum

(Rac)-AMG8380(1641574-26-6)1HNMR
(Rac)-AMG8379 (Rac)-AMG8380 6-Quinolinesulfonamide, 1-(3'-chloro-2,5'-difluoro-5-methoxy[1,1'-biphenyl]-4-yl)-1,2-dihydro-N-3-isoxazolyl-2-oxo- (Rac)-AMG8379, 10 mM in DMSO (Rac)-AMG8379/(Rac)-AMG8380 1641574-26-6 C25H16ClF2N3O5S