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ChemicalBook >> CAS DataBase List >>4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Structure
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- structure
CAS No.
2160546-07-4
Chemical Name:
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
Synonyms
BBP398;BBP-398;BBP 398;IACS13909;IACS15509;IACS-15509;IACS 15509;LACS-13909;BBP- 398 (IACS-13909);IACS-13909, 10 mM in DMSO
CBNumber:
CB18093166
Molecular Formula:
C17H18Cl2N6
Molecular Weight:
377.27
MDL Number:
MFCD32899276
MOL File:
2160546-07-4.mol
MSDS File:
SDS
Last updated:2026-03-18 11:52:23
Product description Number Pack Size Price
IACS-13909 99.93% CS-0136474 5mg $300
IACS-13909 99.93% CS-0136474 10mg $500
IACS-13909 99.93% CS-0136474 25mg $1050
IACS-13909 020571 003 $2400
IACS-13909 020571 001 $700
Request For Quotation

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Properties

Boiling point 577.3±50.0 °C(Predicted)
Density 1.402±0.06 g/cm3(Predicted)
solubility DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form Solid
pka 8.00±0.50(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0136474 IACS-13909 99.93% 2160546-07-4 5mg $300 2021-12-16 Buy
ChemScene CS-0136474 IACS-13909 99.93% 2160546-07-4 10mg $500 2021-12-16 Buy
ChemScene CS-0136474 IACS-13909 99.93% 2160546-07-4 25mg $1050 2021-12-16 Buy
DC Chemicals 020571 IACS-13909 2160546-07-4 003 $2400 2021-12-16 Buy
DC Chemicals 020571 IACS-13909 2160546-07-4 001 $700 2021-12-16 Buy
Product number Packaging Price Buy
CS-0136474 5mg $300 Buy
CS-0136474 10mg $500 Buy
CS-0136474 25mg $1050 Buy
020571 003 $2400 Buy
020571 001 $700 Buy

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Chemical Properties,Uses,Production

Uses

IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers[1].

in vivo

IACS-13909 (70 mg/kg; oral administration; daily; for 21 days) treatment potently suppresses tumor growth in mice, with 100% tumor growth inhibition (TGI) observed following 21 days of dosing[1].

Animal Model:NSG mice (20-28 g) injected with KYSE-520 cells[1]
Dosage:70 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Potently suppressed tumor growth in mice.

References

[1] Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 Nov 1;80(21):4840-4853. DOI:10.1158/0008-5472.CAN-20-1634
[2] BARBARA CZAKO*. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor[J]. Journal of Medicinal Chemistry, 2021, 64 20: 15141-15169. DOI: 10.1021/acs.jmedchem.1c01132

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Suppliers

Global( 60)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32469 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39042 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 8616 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 18971495150; sales@sun-shinechem.com China 1136 64
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64

View Lastest Price from 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IACS-13909 pictures 2026-03-13 IACS-13909
2160546-07-4
 US $96.00-378.00 / mg 98.83% 10g TargetMol Chemicals Inc.
  • IACS-13909 pictures
  • IACS-13909
    2160546-07-4
  • US $96.00-378.00 / mg
  • 98.83%
  • TargetMol Chemicals Inc.

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Spectrum

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-(2160546-07-4)1HNMR

2160546-07-4(4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-)Related Search:

Glucosamine
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- IACS13909 LACS-13909 BBP 398 BBP398 BBP-398 IACS 15509 IACS15509 IACS-15509 antiproliferative,RTK,IACS13909,inhibit,SHP2,pMEK,anticancer,Inhibitor,MAPK,IACS 13909,pERK,Phosphatase,IACS-13909 IACS-13909, 10 mM in DMSO BBP- 398 (IACS-13909) 2160546-07-4 C17H18Cl2N6