4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-

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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- manufacturers

  • IACS-13909
  • IACS-13909 pictures
  • $96.00
  • 2026-07-27
  • CAS:2160546-07-4
  • Purity: 98.83%
  • Supply Ability: 10g
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Basic information
Product Name:4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
Synonyms:4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-;IACS13909;LACS-13909;BBP 398;BBP398;IACS 15509;IACS15509;IACS-15509
CAS:2160546-07-4
MF:C17H18Cl2N6
MW:377.27
EINECS:
Product Categories:
Mol File:2160546-07-4.mol
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Structure
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Chemical Properties
Boiling point 577.3±50.0 °C(Predicted)
density 1.402±0.06 g/cm3(Predicted)
solubility DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form Solid
pka8.00±0.50(Predicted)
color White to yellow
Safety Information
MSDS Information
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Usage And Synthesis
UsesIACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers[1].
in vivo

IACS-13909 (70 mg/kg; oral administration; daily; for 21 days) treatment potently suppresses tumor growth in mice, with 100% tumor growth inhibition (TGI) observed following 21 days of dosing[1].

Animal Model:NSG mice (20-28 g) injected with KYSE-520 cells[1]
Dosage:70 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Potently suppressed tumor growth in mice.
References[1] Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 Nov 1;80(21):4840-4853. DOI:10.1158/0008-5472.CAN-20-1634
[2] BARBARA CZAKO*. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor[J]. Journal of Medicinal Chemistry, 2021, 64 20: 15141-15169. DOI: 10.1021/acs.jmedchem.1c01132
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Preparation Products And Raw materials
Tag:4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-(2160546-07-4) Related Product Information
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