ChemicalBook >> CAS DataBase List >>L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-

L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-

L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- structure

CAS No.: 2294820-23-6

Chemical Name:: L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-

Synonyms: AGF347;L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-

CBNumber:: CB18119097

Molecular Formula:: C22H24FN5O6

Molecular Weight:: 473.45

MDL Number:

MOL File:: 2294820-23-6.mol

Last updated:2026-01-13 11:13:54

Request For Quotation

L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Properties

Density	1.53±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 2mg/L, clear
pka	3.53±0.10(Predicted)
form	powder
color	white to beige
SMILES	O=C(CC[C@H](NC(C1=CC=C(C=C1F)CCCCN2C=CC(N=C(N3)N)=C2C3=O)=O)C(O)=O)O
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Chemical Properties, Uses, Production

Biological Activity

AGF347 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) th at inhibits mitochondrial C1 metabolism. It also inhibits cytosolic C1 targets such as SHMT1, GARFTase, and AICARFTase. AGF347 inhibits de novo purine biosynthesis. AGF347 exhibits potent broad spectrum in vitro and in vivo antitumor efficacy.

L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
Merck KGaA	--	ordercn@merckgroup.com	China	6376	58

Supplier	Advantage
Merck KGaA	58

L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- AGF347 2294820-23-6 C22H24FN5O6