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ChemicalBook >> CAS DataBase List >>1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Structure
1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- structure
CAS No.
2375740-98-8
Chemical Name:
1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-
Synonyms
CSN5i-3, 10 mM in DMSO;3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide;3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-
CBNumber:
CB18233045
Molecular Formula:
C28H29F2N5O2
Molecular Weight:
505.56
MDL Number:
MFCD31657416
MOL File:
2375740-98-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Request For Quotation

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Properties

Boiling point 666.5±55.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C, protect from light, stored under nitrogen
solubility DMSO:50.56(Max Conc. mg/mL);100.0(Max Conc. mM)
pka 12.66±0.70(Predicted)
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth AVD74098 CSN5i-3 2375740-98-8 1mg $894.93 2026-06-04 Buy
Biosynth AVD74098 CSN5i-3 2375740-98-8 5mg $2529.15 2026-06-04 Buy
Biosynth AVD74098 CSN5i-3 2375740-98-8 10mg $4046.5 2026-06-04 Buy
Biosynth AVD74098 CSN5i-3 2375740-98-8 25mg $7587.5 2026-06-04 Buy
Biosynth AVD74098 CSN5i-3 2375740-98-8 50mg $12140 2026-06-04 Buy
Product number Packaging Price Buy
AVD74098 1mg $894.93 Buy
AVD74098 5mg $2529.15 Buy
AVD74098 10mg $4046.5 Buy
AVD74098 25mg $7587.5 Buy
AVD74098 50mg $12140 Buy

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Chemical Properties, Uses, Production

Uses

CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM[1].

in vivo

CSN5i-3 shows a good pharmacokinetic profile. Treatment with CSN5i-3 triggers the formation of cleaved PARP and cleaved caspase 3 indicative of apoptosis induction[1].

storage

Store at -20°C

References

[1] Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016 Oct 24;7:13166. DOI:10.1038/ncomms13166

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Suppliers

Global Suppliers ( 31)
Supplier Tel Email Country ProdList Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9867 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Hubei wei shi reagent group ltd., company 027-59102966 18717199209 2853877583@qq.com China 2896 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Pushan Industry (Shaanxi) Co., Ltd. 029-81310890 18165209495 2929288192@qq.com China 9949 58
Vicbio Biotechnology Co., Ltd. 13621190864 13691409741 info@vicbio.com China 13147 58
Supplier Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai SuperLan Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Hubei wei shi reagent group ltd., company 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Pushan Industry (Shaanxi) Co., Ltd. 58
Vicbio Biotechnology Co., Ltd. 58

View Latest Price from 1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CSN5i-3 pictures 2026-07-16 CSN5i-3
2375740-98-8
 $378.00-1230.00 99.94% 10g TargetMol Chemicals Inc.
CSN5i-3 pictures 2026-07-15 CSN5i-3
2375740-98-8
 $378.00-1230.00 99.94% 10g TargetMol Chemicals Inc.
  • CSN5i-3 pictures
  • CSN5i-3
    2375740-98-8
  • $378.00-1230.00
  • 99.94%
  • TargetMol Chemicals Inc.
  • CSN5i-3 pictures
  • CSN5i-3
    2375740-98-8
  • $378.00-1230.00
  • 99.94%
  • TargetMol Chemicals Inc.

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Spectrum

1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-(2375740-98-8)1HNMR

2375740-98-8 (1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-) Related Search:

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1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- 3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide CSN5i-3, 10 mM in DMSO 3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide 2375740-98-8 C28H29F2N5O2 CSN5i-3