1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-

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1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Suppliers list
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1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- manufacturers

  • CSN5i-3
  • CSN5i-3 pictures
  • $378.00
  • 2026-07-16
  • CAS:2375740-98-8
  • Purity: 99.94%
  • Supply Ability: 10g
  • CSN5i-3
  • CSN5i-3 pictures
  • $378.00
  • 2026-07-15
  • CAS:2375740-98-8
  • Purity: 99.94%
  • Supply Ability: 10g
1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Basic information
Product Name:1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-
Synonyms:1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-;3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide;CSN5i-3, 10 mM in DMSO;3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide
CAS:2375740-98-8
MF:C28H29F2N5O2
MW:505.56
EINECS:
Product Categories:CSN5i-3
Mol File:2375740-98-8.mol
1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Structure
1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Chemical Properties
Boiling point 666.5±55.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C, protect from light, stored under nitrogen
solubility DMSO:50.56(Max Conc. mg/mL);100.0(Max Conc. mM)
pka12.66±0.70(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Usage And Synthesis
UsesCSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM[1].
in vivo

CSN5i-3 shows a good pharmacokinetic profile. Treatment with CSN5i-3 triggers the formation of cleaved PARP and cleaved caspase 3 indicative of apoptosis induction[1].

storageStore at -20°C
References[1] Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016 Oct 24;7:13166. DOI:10.1038/ncomms13166
1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- Preparation Products And Raw materials
Tag:1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-(2375740-98-8) Related Product Information
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