ChemicalBook >> CAS DataBase List >>Dexamethasone EP Impurity E
Dexamethasone EP Impurity E
- CAS No.
- 13209-41-1
- Chemical Name:
- Dexamethasone EP Impurity E
- Synonyms
- (16alpha)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione;VBP15;Dexamethasone EP Imp E;Dexamethasone impurity E;Dexamethasone Impurity L;Carbamazepine Impurity 22;Vamorolone, 10 mM in DMSO;(8S,10S,13S,14S,16R,17R)-17-hydroxy;16α-Methyl-9,11-dehydro Prednisolone;Tobramycin and dexamethasone impurity C
- CBNumber:
- CB1921384
- Molecular Formula:
- C22H28O4
- Molecular Weight:
- 356.46
- MDL Number:
- MFCD18452727
- MOL File:
- 13209-41-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
| Melting point | 228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3)) |
|---|---|
| Boiling point | 548.3±50.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Dioxane (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 12.53±0.70(Predicted) |
| color | Pale Yellow |
| InChIKey | ZYTXTXAMMDTYDQ-JBFVNPOPNA-N |
| SMILES | C1(=O)C=C2[C@](C)(C=C1)C1[C@]([H])([C@@]3([H])[C@@](CC=1)(C)[C@@](O)(C(=O)CO)[C@H](C)C3)CC2 |&1:4,9,11,13,17,23,r| |
| FDA UNII | 8XP29XMB43 |
| UNSPSC Code | 12352200 |
| NACRES | NA.84 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P261-P264-P272-P280-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Sens. 1 |
Dexamethasone EP Impurity E price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM25760 | 16a-Methyl-9,11-dehydro prednisolone | 13209-41-1 | 25mg | $290.75 | 2026-06-04 | Buy |
| Biosynth | FM25760 | 16a-Methyl-9,11-dehydro prednisolone | 13209-41-1 | 50mg | $484 | 2026-06-04 | Buy |
| Biosynth | FM25760 | 16a-Methyl-9,11-dehydro prednisolone | 13209-41-1 | 100mg | $808 | 2026-06-04 | Buy |
| Biosynth | FM25760 | 16a-Methyl-9,11-dehydro prednisolone | 13209-41-1 | 250mg | $1682.5 | 2026-06-04 | Buy |
| Biosynth | BM300100 | 16a-Methyl-9,11-dehydro prednisolone - Bio-X ™ | 13209-41-1 | 10mg | $199.4 | 2026-06-04 | Buy |
Dexamethasone EP Impurity E Chemical Properties,Uses,Production
Uses
A related intermediate of Prednisolone (P703740).
Biological Activity
Vamorolone, a synthetic steroid, is an orally available dissociative steroid with anti-inflammatory efficacy. It is a partial agonist of the glucocorticoid receptor (NR3C1) th at appear to be safe and well tolerated. Also, vamorolone is a potent antagonist of the mineralocorticoid receptor (NR3C2). It is under development for children with Duchenne muscular dystrophy.
in vivo
Vamorolone (5-30 mg/kg; cherry syrup) shows a superior side effect profile compared to pharmacological glucocorticoids in mdx mice[1].
Vamorolone (30 mg/kg; orally; daily for 20 days) reduces CNS Inflammation in murine experimental autoimmune encephalomyelitis[2].
| Animal Model: | C57BL/6 mice (experimental autoimmune encephalomyelitis)[2] |
| Dosage: | 30 mg/kg |
| Administration: | Orally; daily for 20 days (starting one day prior to MOG 33-55 peptide immunization and continuing) |
| Result: | Reduced CNS inflammation in murine experimental autoimmune encephalomyelitis. |
Toxics Screening Level
The ITSL for 17, 21-dihydroxy-16 alpha-methylpregna-1,4,9 (11)-triene-3, 20-dione has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on annual averaging time.
Dexamethasone EP Impurity E Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 104)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beyond Pharmaceutical Co., Ltd | 0571-81953185 +86-15381198709 | jasonyao@bydpharma.com | China | 852 | 60 |
| Jinan Cen Ben Medical Technology Co., Ltd | 14793566 | info@cenpharm.com | China | 785 | 58 |
| LangFangshi Zekang Pharma Tech CO.,Itd. | 0316-2883536 19333636468 | 93618484@qq.com | China | 2818 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shandong Boluoda Biological Technology Co., Ltd. | 0531-68651502 | 2310993908@qq.com | China | 3157 | 58 |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 15250997978 | 1511893459@qq.com | China | 4777 | 55 |
| Shanghai eliv pharmaceutical Co.,Ltd. | 021-50158063 | sales@elivpharma.com | China | 480 | 58 |
View Lastest Price from Dexamethasone EP Impurity E manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Vamorolone
13209-41-1
|
$31.00-72.00 | 99.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-12 | Dexamethasone EP Impurity E
13209-41-1
|
10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- Vamorolone
13209-41-1
- $31.00-72.00
- 99.57%
- TargetMol Chemicals Inc.
-
- Dexamethasone EP Impurity E
13209-41-1
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
13209-41-1(Dexamethasone EP Impurity E)Related Search:
PSXDNQUHAFMVPT-NWQAGDSVSA-N
Dexamethasone 21-Propionate
Dexamethasone EP Impurity K
HRPWQACPJGPYRH-XHFUFBBFSA-N
2-Methyltetrahydropyran
Betamethasone
1,2-Dihydro Dexamethasone
17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
Dexamethasone 21-phosphate disodium salt
Dexamethasone palmitate
1of4
17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione
16α-Methyl-9,11-dehydro Prednisolone
Dexamethasone impurity E
Dexamethasone Impurity 5(Dexamethasone EP Impurity E)
(16α)-17,21-Dihydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione
17.alpha.,21-Dihydroxy-16.alpha.-methylpregna-1,4,9(11)-triene-3,20-dione
Dexamethasone Impurity L
(8S,10S,13S,14S,16R,17R)-17-hydroxy
Dexamethasone EP Imp E
(8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one
((2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,11-dihydroxy-3,10a,12a-trimethyl-1,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydrochrysen-2-yl)methyl dihydrogen phosphate
17, 21-dihydroxy-16α-methylpregna- 1, 4, 9(11)-triene-3,20-dione
ethyl (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
VBP15
inhibit,repair,Mineralocorticoid Receptor,VBP 15,Glucocorticoid Receptor,NF-κB,inflammation,Duchenne,Inhibitor,membrane,dystrophy,Vamorolone,Nuclear factor-κB,Nuclear factor-kappaB,muscular,VBP-15,glucocorticoid
Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16-methyl-, (16α)-
Tobramycin and dexamethasone impurity C
Carbamazepine Impurity 22
Vamorolone, 10 mM in DMSO
16a-Methyl-9,11-dehydro prednisolone - Bio-X ?
16Alpha-Methyl-9,11-dehydro Prednisolone
(16alpha)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
(8S,10S,13S,14S,16R,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one (Dexamethasone impurity)
13209-41-1
Intermediates & Fine Chemicals
Pharmaceuticals
Steroids
API
