16α-Methyl-11-oxo Prednisolone
- CAS No.
- 2036-77-3
- Chemical Name:
- 16α-Methyl-11-oxo Prednisolone
- Synonyms
- DMS-0;Dexamethasone imp J;Carbamazepine Impurity 26;(8S,9S,10R,13S,14S,16R,17R);Dexamethasone EP Impurity J;16α-Methyl-11-oxo Prednisolone;16Alpha-Methyl-11-oxo Prednisolone;Tobramycin and dexamethasone impurity J;Dexamethasone impurity 4/Dexamethasone EP Impurity J;Dexamethasone Impurity 10(Dexamethasone EP Impurity J)
- CBNumber:
- CB22544463
- Molecular Formula:
- C22H28O5
- Molecular Weight:
- 372.45
- MDL Number:
- MFCD31563183
- MOL File:
- 2036-77-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 16α-Methyl-11-oxo Prednisolone | AA00C2RV | 100mg | $920 |
| 16α-Methyl-11-oxoPrednisolone | M295350 | 25mg | $850 |
| 16-ALPHA-METHYL-11-OXO PREDNISOLONE 95.00% | SHG0005877 | 5MG | $496.54 |
| More product size | |||
| Melting point | 197-199°C |
|---|---|
| Boiling point | 574.4±50.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.38±0.70(Predicted) |
| color | White to Off-White |
| Major Application | pharmaceutical small molecule |
| FDA UNII | NJ0LL8HN9X |
16α-Methyl-11-oxo Prednisolone price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00C2RV | 16α-Methyl-11-oxo Prednisolone | 2036-77-3 | 100mg | $920 | 2026-05-28 | Buy |
| TRC | M295350 | 16α-Methyl-11-oxoPrednisolone | 2036-77-3 | 25mg | $850 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0005877 | 16-ALPHA-METHYL-11-OXO PREDNISOLONE 95.00% | 2036-77-3 | 5MG | $496.54 | 2021-12-16 | Buy |
16α-Methyl-11-oxo Prednisolone Chemical Properties,Uses,Production
Uses
A 16α-substituted Prednisolone as potent topical antiinflammatory agent.
Synthesis
1) Add 5.0 g of pregnane-1,4,16-triene-3,11,20-trione (compound (I-1)) with 0.02 times copper bromide dimethyl sulfide, 1.2 times trimethylchlorosilane, 2 times hexamethylphosphorotriamine to 60 ml of tetrahydrofuran, and slowly add 1.2 times methylmagnesium bromide dissolved in the tetrahydrofuran to carry out the Grignard reaction, the temperature of the reaction is -30-20. The reaction was protected by passing N2, and at the end of the reaction it was diluted with water, separated and dried to obtain the Grignard product (compound (II-1)); 2) React the above Grignard with 3 times potassium bicarbonate and 1.5 times m-chloroperoxybenzoic acid in dichloromethane at a reaction temperature of -30 to -25C, and react until complete. The solution pH was adjusted to 1 with hydrochloric acid, concentrated under reduced pressure, cooled, separated and dried to obtain the compound dexamethasone EP impurity J(III-1), total yield 78.2%.
16α-Methyl-11-oxo Prednisolone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| BTC pharm India | +918790379245 | banny.janga@btcpharm.com | India | 1262 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 10000 | 58 |
| LangFangshi Zekang Pharma Tech CO.,Itd. | 0316-2883536 19333636468 | 93618484@qq.com | China | 2771 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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