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ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Structure
Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) structure
CAS No.
2310299-91-1
Chemical Name:
Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
Synonyms
Gefapixant citrate;Gefapixant Citrat;methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Jifa Pisheng Citrate;Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
CBNumber:
CB19319045
Molecular Formula:
C20H27N5O11S
Molecular Weight:
545.52
MDL Number:
MOL File:
2310299-91-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-30 10:48:35
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Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Properties

form Solid
color White to off-white
InChIKey AIJVJYUOMCRFOE-UHFFFAOYSA-N
SMILES C(O)(C(=O)O)(CC(=O)O)CC(=O)O.O(C1=CN=C(N)N=C1N)C1C=C(S(=O)(=O)N)C(OC)=CC=1C(C)C
FDA UNII DFK0FC2VVV

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0377571 Gefapixant citrate 99.23% 2310299-91-1 5mg $97 2026-06-04 Buy
ChemScene CS-0377571 Gefapixant citrate 99.23% 2310299-91-1 10mg $152 2026-06-04 Buy
ChemScene CS-0377571 Gefapixant citrate 99.23% 2310299-91-1 25mg $303 2026-06-04 Buy
ChemScene CS-0377571 Gefapixant citrate 99.23% 2310299-91-1 50mg $455 2026-06-04 Buy
ChemScene CS-0377571 Gefapixant citrate 99.23% 2310299-91-1 100mg $682 2026-06-04 Buy
Product number Packaging Price Buy
CS-0377571 5mg $97 Buy
CS-0377571 10mg $152 Buy
CS-0377571 25mg $303 Buy
CS-0377571 50mg $455 Buy
CS-0377571 100mg $682 Buy

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Chemical Properties, Uses, Production

Uses

Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis[1][2][3].

in vivo

Gefapixant citrate (7d bid, orally) attenuates the weight bearing laterality with complete reversal of apparent hyperalgesia at the two higher doses in a rat model of knee osteoarthritis (14d following intra-articular administration of monoiodoacetate)[2].

IC 50

P2X3 Receptor

References

[1] Anthony P. Ford, et al. The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders. Front Cell Neurosci. 2013; 7: 267. DOI:10.3389/fncel.2013.00267
[2] Ford AP, In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. Purinergic Signal. 2012 Feb;8(Suppl 1):3-26. DOI:10.1007/s11302-011-9271-6
[3] Martin Nguyen A, et al. Validation of a visual analog scale for assessing cough severity in patients with chronic cough. Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211049743. DOI:10.1177/17534666211049743

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Suppliers

Global Suppliers ( 30)
Supplier Tel Email Country ProdList Advantage
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636 wtx@bayeebio.com China 145 61
Hangzhou Kehui Pharmaceutical Co.,Ltd 0571-87359773 18094707759 sales10@hzkehuipharma.com China 68 58
Shenzhen Yaoyuan R&D Center Co., Ltd 23284190 13421666688 664261110@qq.com China 88 58
Beijing Mesochem Technology Co., Ltd. 010-57862036 18811083386; msales@mesochem.com China 209 58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8696 58
Hubei widely chemical technology Co., Ltd. 17771478861 13419635609 3525818213@qq.com China 1887 55
Jinan Guoding Pharmaceutical Technology Co., Ltd. 053167801621 15665775653 sales@guodingpharma.com China 479 58
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29091 58
Nanjing Feihao Technology Co., Ltd. 025-58855213 hongjiling@feihongtec.com China 782 58
Hubei Weideli Chemical Reagent Co., Ltd. 13429867250 13429867250 w13429867250@163.com China 1923 58
Supplier Advantage
Bayee Biotech (Anqing) Co., Ltd. 61
Hangzhou Kehui Pharmaceutical Co.,Ltd 58
Shenzhen Yaoyuan R&D Center Co., Ltd 58
Beijing Mesochem Technology Co., Ltd. 58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Hubei widely chemical technology Co., Ltd. 55
Jinan Guoding Pharmaceutical Technology Co., Ltd. 58
Dideu Industries Group Limited 58
Nanjing Feihao Technology Co., Ltd. 58
Hubei Weideli Chemical Reagent Co., Ltd. 58

View Latest Price from Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gefapixant Citrate pictures 2026-09-16 Gefapixant Citrate
2310299-91-1
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Gefapixant Citrate. pictures 2026-09-16 Gefapixant Citrate.
2310299-91-1
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Gefapixant citrate pictures 2026-07-29 Gefapixant citrate
2310299-91-1
 $31.00-129.00 99.51% 10g TargetMol Chemicals Inc.
  • Gefapixant Citrate pictures
  • Gefapixant Citrate
    2310299-91-1
  • $0.00
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
  • Gefapixant Citrate. pictures
  • Gefapixant Citrate.
    2310299-91-1
  • $0.00
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Spectrum

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)(2310299-91-1)1HNMR

2310299-91-1 (Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)) Related Search:

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Gefapixant SODIUM METATUNGSTATE N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride 2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt
Ion Channel Compound Library

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Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Jifa Pisheng Citrate Gefapixant citrate Gefapixant Citrat methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) 2310299-91-1 1451393-02-8 C20H27N5O11S API