2-Methoxy-5-fluoro-4-aminopyrimidine
- CAS No.
- 1993-63-1
- Chemical Name:
- 2-Methoxy-5-fluoro-4-aminopyrimidine
- Synonyms
- 5-Fluoro-2-MethoxypyriMidin-4-aMine;5-Fluoro-2-methoxy-4-pyrimidinamine;4-AMINO-5-FLUORO-2-METHOXYPYRIMIDINE;2-Methoxy-5-fluoro-4-aminopyrimidine;4-Pyrimidinamine, 5-fluoro-2-methoxy;5-Fluoro-2-methoxy-pyrimidin-4-ylamine;4-Amino-5-fluoro-2-methoxypyrimidine >4-Pyrimidinamine, 5-fluoro-2-methoxy- (9CI);2-Methoxy-5-fluoro-4-aminopyrimidine ISO 9001：2015 REACH;2-methoxy-5-fluoro-4-aminopyrimidine (intermediate of flucytosine)
- CBNumber:
- CB1946996
- Molecular Formula:
- C5H6FN3O
- Molecular Weight:
- 143.12
- MDL Number:
- MFCD09264289
- MOL File:
- 1993-63-1.mol
- MSDS File:
- SDS
| Melting point | 193 °C |
|---|---|
| Boiling point | 278.9±43.0 °C(Predicted) |
| Density | 1.345±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.63±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C5H6FN3O/c1-10-5-8-2-3(6)4(7)9-5/h2H,1H3,(H2,7,8,9) |
| InChIKey | BYALTIIVASWNSY-UHFFFAOYSA-N |
| SMILES | C1(OC)=NC=C(F)C(N)=N1 |
| CAS DataBase Reference | 1993-63-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| HS Code | 2933599590 | |||||||||
| NFPA 704 |
|
2-Methoxy-5-fluoro-4-aminopyrimidine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2125 | 4-Amino-5-fluoro-2-methoxypyrimidine >99.0%(T) | 1993-63-1 | 5g | $287 | 2026-04-30 | Buy |
| Apolloscientific | PC906580 | 4-Amino-5-fluoro-2-methoxypyrimidine >98% | 1993-63-1 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC906580 | 4-Amino-5-fluoro-2-methoxypyrimidine >98% | 1993-63-1 | 25g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC906580 | 4-Amino-5-fluoro-2-methoxypyrimidine >98% | 1993-63-1 | 100g | $90 | 2026-06-04 | Buy |
| Apolloscientific | PC906580 | 4-Amino-5-fluoro-2-methoxypyrimidine >98% | 1993-63-1 | 500g | $444 | 2026-06-04 | Buy |
2-Methoxy-5-fluoro-4-aminopyrimidine Chemical Properties, Uses, Production
Uses
2-Methoxy-5-fluoro-4-aminopyrimidine is an intermediate of fluorocytosine.
Synthesis
1801-06-5
1993-63-1
General procedure for the synthesis of 5-fluoro-2-methoxy-4-fluoropyrimidinamine using 2-methoxy-4-chloro-5-fluoropyrimidine as starting material: 32.5 g of 2-methoxy-4-chloro-5-fluoropyrimidine (compound of formula III) was added to 170 g of a 10 wt% solution of isopropanol in ammonia, heated to 40-60 °C, and the reaction was stirred for 3-5 hours. After completion of the reaction, it was naturally cooled to room temperature and the solid product was collected by filtration. The solid was washed with isopropanol and dried to give 27.2 g of 5-fluoro-2-methoxy-4-pyrimidinamine (compound of formula II, white solid) in 95.0% molar yield and 99.0% HPLC purity.
References
[1] Patent: CN105272922, 2016, A. Location in patent: Paragraph 0038; 0039; 0040
2-Methoxy-5-fluoro-4-aminopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Easichem Co. ltd. | 18061688856 | easichem@126.com | China | 477 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Latest Price from 2-Methoxy-5-fluoro-4-aminopyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 2-Methoxy-5-fluoro-4-aminopyrimidine
1993-63-1
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-06-20 | 2-Methoxy-5-fluoro-4-aminopyrimidine
1993-63-1
|
$1.00 | 1kg | 98.00% | 20tons | Hebei Yanxi Chemical Co., Ltd. |
-
- 2-Methoxy-5-fluoro-4-aminopyrimidine
1993-63-1
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Methoxy-5-fluoro-4-aminopyrimidine
1993-63-1
- $1.00
- 98.00%
- Hebei Yanxi Chemical Co., Ltd.
