MMP13-IN-31f
- CAS No.
- 935759-55-0
- Chemical Name:
- MMP13-IN-31f
- Synonyms
- MMP13-IN-2;MMP13-IN-31f;Thieno[2,3-d]pyrimidine-2-carboxamide, 5-(3-fluorophenyl)-1,4-dihydro-4-oxo-N-[[3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]phenyl]methyl]-
- CBNumber:
- CB19628154
- Molecular Formula:
- C24H19FN6O4S
- Molecular Weight:
- 506.51
- MDL Number:
- MOL File:
- 935759-55-0.mol
- MSDS File:
- SDS
MMP13-IN-31f price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0087570 | MMP13-IN-2 99.13% | 935759-55-0 | 5mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-0087570 | MMP13-IN-2 99.13% | 935759-55-0 | 10mg | $737 | 2026-06-04 | Buy |
| ChemScene | CS-0087570 | MMP13-IN-2 99.13% | 935759-55-0 | 25mg | $1462 | 2026-06-04 | Buy |
| ChemScene | CS-0087570 | MMP13-IN-2 99.13% | 935759-55-0 | 50mg | $2383 | 2026-06-04 | Buy |
| ChemScene | CS-0087570 | MMP13-IN-2 99.13% | 935759-55-0 | 100mg | $3683 | 2026-06-04 | Buy |
MMP13-IN-31f Chemical Properties,Uses,Production
Uses
MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research[1].
in vivo
MMP13-IN-2 (oral gavage; 1 mg/kg) shows the best combination of CYP3A4 inhibition risk and oral exposure at a dose of 1 mg/kg in rats and mice (F% = 33 and 38, respectively)[1].
IC 50
MMP-13: 0.036 nM (IC50); MMP-2: 180 nM (IC50); MMP-3: 1100 nM (IC50)
References
[1] Hiroshi Nara, et al. Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach. J Med Chem. 2017 Jan 26;60(2):608-626. DOI:10.1021/acs.jmedchem.6b01007
MMP13-IN-31f Preparation Products And Raw materials
Raw materials
Preparation Products
MMP13-IN-31f Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 60 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
