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ChemicalBook >> CAS DataBase List >>3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]-

3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]-

3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- Structure
3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- structure
CAS No.
905585-60-6
Chemical Name:
3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]-
Synonyms
AZD-6918;3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]-
CBNumber:
CB19783707
Molecular Formula:
C20H20F2N6O
Molecular Weight:
398.41
MDL Number:
MOL File:
905585-60-6.mol
MSDS File:
SDS
Last updated:2026-05-11 16:31:51
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3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- Properties

Boiling point 546.1±50.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
pka 12.06±0.10(Predicted)

3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- Chemical Properties, Uses, Production

Description

AZD6918 is a novel potent and selective inhibitor of the Trk tyrosine kinases. AZD-6918 attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. AZD6918 inhibited wild-type TrkB-induced cell migration and cell growth.

Uses

AZD6918 is an orally active and selective Trk tyrosine kinase inhibitor. AZD6918 induces cell death as a single agent and attenuates BDNF/TrkB-induced protection from Etoposide (HY-13629) in vitro. AZD6918 can be used for the research of neuroblastoma[1].

References

[1] Li Z, et al. Trk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. Cancer Biol Ther. 2015;16(3):477-83. DOI:10.1080/15384047.2015.1016659

3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Shanghai Merlot Chemical Co., LTD 15821661757 226174156@qq.com China 476 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shanghai Merlot Chemical Co., LTD 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZD-6918 pictures 2026-05-11 AZD-6918
905585-60-6
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
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    905585-60-6
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905585-60-6 (3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]-) Related Search:

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3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[[5-(1-methylethoxy)-1H-pyrazol-3-yl]amino]- AZD-6918 905585-60-6