Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-
![Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Structure](CAS/20210305/GIF/1007377-55-0.gif)
- CAS No.
- 1007377-55-0
- Chemical Name:
- Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-
- Synonyms
- AKB6899;AKB-6899;AKB 6899;AKB-6899, 10 mM in DMSO;Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-;antiangiogenic,Inhibitor,AKB 6899,antitumor,AKB-6899,HIF-PH,HIF-2α,sVEGFR-1,HIF/HIF Prolyl-Hydroxylase,HIFs,inhibit,Hypoxia-inducible factors,PHD3
- CBNumber:
- CB19796110
- Molecular Formula:
- C14H11FN2O4
- Molecular Weight:
- 290.25
- MDL Number:
- MFCD32204728
- MOL File:
- 1007377-55-0.mol
| Boiling point | 653.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.436±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 4.09±0.40(Predicted) |
| color | White to yellow |
| FDA UNII | ZIA31378BO |
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Chemical Properties,Uses,Production
Uses
AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects[1].
in vivo
AKB-6899 (17.5 mg/kg; i.p.; 3 times per week; for 16 days) treatment significantly reduces tumor growth in a murine melanoma model[1].
| Animal Model: | 6-8-week-old C57BL/6 mice injected with B16F10 murine melanoma cells[1] |
| Dosage: | 17.5 mg/kg |
| Administration: | i.p.; 3 times per week; for 16 days |
| Result: | Significantly reduced tumor growth. |
References
[1] Julie M Roda, et al. Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model. J Immunol. 2012 Sep 15;189(6):3168-77. DOI:10.4049/jimmunol.1103817
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4472 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24863 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 55710 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12000 | 58 |
