Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-

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Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Suppliers list
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
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Company Name: Shanghai Dongyang Biotechnology Co., Ltd.  
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Company Name: ShangHai ChuanQian Chemcial Technique Centre  
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@tsbiochem.com

Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- manufacturers

  • AKB-6899
  • AKB-6899 pictures
  • $71.00
  • 2026-07-27
  • CAS:1007377-55-0
  • Purity: 97.87%
  • Supply Ability: 10g
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Basic information
Product Name:Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-
Synonyms:Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-;AKB 6899;AKB6899;AKB-6899;antiangiogenic,Inhibitor,AKB 6899,antitumor,AKB-6899,HIF-PH,HIF-2α,sVEGFR-1,HIF/HIF Prolyl-Hydroxylase,HIFs,inhibit,Hypoxia-inducible factors,PHD3;AKB-6899, 10 mM in DMSO
CAS:1007377-55-0
MF:C14H11FN2O4
MW:290.25
EINECS:
Product Categories:
Mol File:1007377-55-0.mol
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Structure
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Chemical Properties
Boiling point 653.5±55.0 °C(Predicted)
density 1.436±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka4.09±0.40(Predicted)
color White to yellow
Safety Information
MSDS Information
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Usage And Synthesis
UsesAKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects[1].
in vivo

AKB-6899 (17.5 mg/kg; i.p.; 3 times per week; for 16 days) treatment significantly reduces tumor growth in a murine melanoma model[1].

Animal Model:6-8-week-old C57BL/6 mice injected with B16F10 murine melanoma cells[1]
Dosage:17.5 mg/kg
Administration:i.p.; 3 times per week; for 16 days
Result:Significantly reduced tumor growth.
References[1] Julie M Roda, et al. Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model. J Immunol. 2012 Sep 15;189(6):3168-77. DOI:10.4049/jimmunol.1103817
Glycine, N-[[5-(3-fluorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- Preparation Products And Raw materials
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