Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]-

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]-

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- Structure
2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- structure
CAS No.
2677786-27-3
Chemical Name:
2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]-
Synonyms
GRK6-IN-2;2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]-
CBNumber:
CB19934671
Molecular Formula:
C21H21FN6
Molecular Weight:
376.43
MDL Number:
MOL File:
2677786-27-3.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:46
Request For Quotation

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- Properties

Boiling point 612.5±65.0 °C(Predicted)
Density 1.334±0.06 g/cm3(Predicted)
pka 14.27±0.10(Predicted)
form Solid
color White to off-white

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0373119 GRK6/Aurora A-IN-1 98.98% 2677786-27-3 5mg $130 2026-06-04 Buy
ChemScene CS-0373119 GRK6/Aurora A-IN-1 98.98% 2677786-27-3 10mg $217 2026-06-04 Buy
ChemScene CS-0373119 GRK6/Aurora A-IN-1 98.98% 2677786-27-3 25mg $422 2026-06-04 Buy
ChemScene CS-0373119 GRK6/Aurora A-IN-1 98.98% 2677786-27-3 50mg $650 2026-06-04 Buy
ChemScene CS-0373119 GRK6/Aurora A-IN-1 98.98% 2677786-27-3 100mg $975 2026-06-04 Buy
Product number Packaging Price Buy
CS-0373119 5mg $130 Buy
CS-0373119 10mg $217 Buy
CS-0373119 25mg $422 Buy
CS-0373119 50mg $650 Buy
CS-0373119 100mg $975 Buy

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- Chemical Properties, Uses, Production

Uses

GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].

References

[1] Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147. DOI:10.1021/acs.jmedchem.1c00506

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- Suppliers

Global Suppliers ( 12)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Zhejiang Huida Biotech Co., Ltd. 0571-89903022 18679456698 zilong@hizyme.com China 7853 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com China 32997 60
Aladdin Scientific tp@aladdinsci.com United States 50068 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai Chaolan Chemical Technology Center 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Amole Biotechnology Co., Ltd. 58
Zhejiang Huida Biotech Co., Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
Aladdin Scientific 58

2677786-27-3 (2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]-) Related Search:

Ethyl 8-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylate AT9283 PF 477736 Anti-Aging Compound Library 2,4-Quinazolinediamine, N2-[(4-chloro-2-methoxyphenyl)methyl]-N4-(5-ethyl-1H-pyrazol-3-yl)-5-methoxy-
Anti-cancer compound library

1of2

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- GRK6-IN-2 2677786-27-3