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Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]-

Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- structure

CAS No.: 869650-21-5

Chemical Name:: Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]-

Synonyms: K00135;K 00135;K-00135;K00135, 10 mM in DMSO;Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]-

CBNumber:: CB210065846

Molecular Formula:: C18H18N4O

Molecular Weight:: 306.36

MDL Number:

MOL File:: 869650-21-5.mol

Last updated:2025-09-28 17:38:58

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Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- Properties

Density	1.33±0.1 g/cm3(Predicted)
pka	4.91±0.30(Predicted)

Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- Chemical Properties,Uses,Production

Description

K00135 is a potent and selective inhibitor of PIM kinases. K00135 was shown to impair survival and clonogenic growth of a panel of human acute leukemia cells. Exposure to K00135 also significantly suppressed in vitro growth of leukemic blasts from five acute myelogenous leukemia patients but not of normal umbilical cord blood mononuclear cells.

Uses

K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets[1].

References

[1] Pogacic V, et al. Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity[J]. Cancer research, 2007, 67(14): 6916-6924.

Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 18100677375	sales@szzxbio.com	China	3000	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29547	58
Sangon Biotech (Shanghai) Co.,Ltd.	400-821-026	Sales@sangon.com	China	6710	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12000	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
Sangon Biotech (Shanghai) Co.,Ltd.	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

View Lastest Price from Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-28	K00135 869650-21-5	US $195.00-449.00 / mg		98.16%	10g	TargetMol Chemicals Inc.

K00135
869650-21-5
US $195.00-449.00 / mg
98.16%
TargetMol Chemicals Inc.

Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- Spectrum

Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]-(869650-21-5)¹HNMR

Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]- K 00135 K00135 K-00135 K00135, 10 mM in DMSO 869650-21-5