PT-ttpy
- CAS No.
- 727721-37-1
- Chemical Name:
- PT-ttpy
- Synonyms
- PT-ttpy;Chloro[4'-(4-methylphenyl)-2,2':6',2''-terpyridine] Platinum(II) chloride
- CBNumber:
- CB210080180
- Molecular Formula:
- C22H17Cl2N3Pt
- Molecular Weight:
- 589.38
- MDL Number:
- MFCD32264619
- MOL File:
- 727721-37-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
PT-ttpy Chemical Properties,Uses,Production
Uses
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
Biological Activity
Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand th at potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
References
[1] P.P. Losada et al.Fresenius Journal of Analytical Chemistry1993
PT-ttpy Preparation Products And Raw materials
Raw materials
Preparation Products
PT-ttpy Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| Changzhou Carman Chemical Co., ltd | 0519-0519-83534936 18151214939 | 1521178147@qq.com | China | 505 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-0371-63284658 18135795563 | 2885349392@qq.com | China | 9992 | 58 |
| Shanghai UCHEM Inc. | 18786204474 18939844854 | sales6@myuchem.com | China | 5051 | 58 |
| Changzhou Run-chem Biotech Co., ltd | 15061933924 | 3301839366@qq.com | China | 826 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39665 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50464 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-025-66113011 18626450290 | cb5@aikonchem.com | China | 10359 | 58 |
| Shanghai Chemilab Biotechnology CO.,Ltd | 18116465878 18116465878 | kmlb@kaimilaibo.com | China | 2627 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |