abecarnil
- CAS No.
- 111841-85-1
- Chemical Name:
- abecarnil
- Synonyms
- ZK-112119;Abercanil;abecarnil;ZK-112-119;6-Benzyloxy-4-methoxymethyl-β-carboline-3-carboxylic acid isopropyl ester;6-(Benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid isopropyl ester;Isopropyl 6-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate;9H-Pyrido[3,4-b]indole-3-carboxylic acid, 4-(methoxymethyl)-6-(phenylmethoxy)-, 1-methylethyl ester
- CBNumber:
- CB21074381
- Molecular Formula:
- C24H24N2O4
- Molecular Weight:
- 404.46
- MDL Number:
- MFCD00865327
- MOL File:
- 111841-85-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 150-151° |
|---|---|
| Boiling point | 620.2±55.0 °C(Predicted) |
| Density | 1.246±0.06 g/cm3(Predicted) |
| pka | 13.98±0.40(Predicted) |
| CAS DataBase Reference | 111841-85-1 |
| FDA UNII | IZM1PNJ3JL |
abecarnil price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0025044 | Abecarnil 99.38% | 111841-85-1 | 5mg | $808 | 2026-06-04 | Buy |
| ChemScene | CS-0025044 | Abecarnil 99.38% | 111841-85-1 | 10mg | $1295 | 2026-06-04 | Buy |
| ChemScene | CS-0025044 | Abecarnil 99.38% | 111841-85-1 | 25mg | $2589 | 2026-06-04 | Buy |
| aablocks | AA008XG2 | abecarnil >98%(orrefertotheCertificateofAnalysis) | 111841-85-1 | 1mg | $153 | 2026-05-28 | Buy |
| aablocks | AA008XG2 | abecarnil >98%(orrefertotheCertificateofAnalysis) | 111841-85-1 | 5mg | $353 | 2026-05-28 | Buy |
abecarnil Chemical Properties, Uses, Production
Description
Abecarnil is a β-carboline-3-carboxylic acid derivative that is in development for the treatment of anxiety disorders. Animal work has shown that abecarnil has a low propensity to cause the problems of dependency and abuse and that the drug has marked anxiolytic and anticonvulsant activity but does not appear to have significant effects on motor coordination—a finding in marked contrast to the effects of diazepam (Stephens et al. 1990). This interesting phenomena may be explained by the fact that abecarnil is acting as a full agonist at some receptors that mediate certain effects (potent anxiolytic) and as a partial agonist at others (lack of side effects). One published clinical study compared abecarnil at different doses with placebo in patients with generalized anxiety disorder (Ballenger et al. 1991). This showed that abecarnil was significantly more effective than placebo in terms of anxiolysis. Stopping treatment produced no withdrawal effects in patients on the lower dose, although some effects were seen in those taking higher doses.
Originator
Abecarnil,Schepa
Uses
Abecarnil is a partial agonist at the benzodiazepine–GABA receptor complex, and is used in generalized anxiety disorder.
Therapeutic Function
Anticonvulsant, Anxiolytic
Hazard
Human systemic effects.
abecarnil Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shenzhen Botel Biotechnology Co. Ltd. | 13316949107 13316968096 | 1979313431@qq.com | China | 9619 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39866 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| Shanghai Easy CDMO Co.,Ltd | Info@easycdmo.com 13564957716 | Info@easycdmo.com | China | 9999 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 10763 | 58 |
