Pipequaline
- CAS No.
- 77472-98-1
- Chemical Name:
- Pipequaline
- Synonyms
- PK-8165;45319RP;RP-45319;Pipequaline;CAS_77472-98-1;pipequaline PK-8165;PK-8165; PK8165; PK 8165;pipequaline HCI(PK-8165);pipequaline.HCl(for free base);2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
- CBNumber:
- CB21179512
- Molecular Formula:
- C22H24N2
- Molecular Weight:
- 316.44
- MDL Number:
- MFCD00866983
- MOL File:
- 77472-98-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 489.2±30.0 °C(Predicted) |
|---|---|
| Density | 1.078±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml |
| form | A crystalline solid |
| pka | 10.60±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | J3S205V4I2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Pipequaline price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23888 | Pipequaline ≥98% | 77472-98-1 | 10mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 23888 | Pipequaline ≥98% | 77472-98-1 | 50mg | $392 | 2026-04-30 | Buy |
| Cayman Chemical | 23888 | Pipequaline ≥98% | 77472-98-1 | 100mg | $653 | 2026-04-30 | Buy |
| ChemScene | CS-6386 | Pipequaline 99.93% | 77472-98-1 | 5mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-6386 | Pipequaline 99.93% | 77472-98-1 | 10mg | $76 | 2026-06-04 | Buy |
Pipequaline Chemical Properties, Uses, Production
Description
Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay). In mice, pipequaline enhances the effects of diazepam , further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects. Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil .
Uses
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].
in vivo
Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].
References
[1] Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. DOI:10.1016/0014-2999(85)90790-3
[2] Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. DOI:10.1016/0028-3908(87)90096-7
Pipequaline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 645 | 55 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1245 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2968 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 9957 | 58 |
| Shanghai Resuperpharmtech Co., Ltd. | 02150565560; 17321237488 | kevin@resuperpharmtech.com | China | 353 | 58 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 |
View Latest Price from Pipequaline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | Pipequaline
77472-98-1
|
$1.00 | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- Pipequaline
77472-98-1
- $1.00
- 97%-99.9%
- Career Henan Chemical Co
