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ChemicalBook >> CAS DataBase List >>Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)-

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)-

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- Structure
Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- structure
CAS No.
2396465-33-9
Chemical Name:
Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)-
Synonyms
GCN2-IN-7;Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)-
CBNumber:
CB212199024
Molecular Formula:
C22H23BrN8OS
Molecular Weight:
527.44
MDL Number:
MOL File:
2396465-33-9.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
Request For Quotation

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- Properties

Density 1.67±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 16.40±0.40(Predicted)
form Solid
color White to off-white

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0613281 GCN2-IN-7 99.92% 2396465-33-9 1mg $406 2026-06-04 Buy
ChemScene CS-0613281 GCN2-IN-7 99.92% 2396465-33-9 5mg $1023 2026-06-04 Buy
ChemScene CS-0613281 GCN2-IN-7 99.92% 2396465-33-9 10mg $1625 2026-06-04 Buy
ChemScene CS-0613281 GCN2-IN-7 99.92% 2396465-33-9 25mg $2769 2026-06-04 Buy
ChemScene CS-0613281 GCN2-IN-7 99.92% 2396465-33-9 50mg $3614 2026-06-04 Buy
Product number Packaging Price Buy
CS-0613281 1mg $406 Buy
CS-0613281 5mg $1023 Buy
CS-0613281 10mg $1625 Buy
CS-0613281 25mg $2769 Buy
CS-0613281 50mg $3614 Buy

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- Chemical Properties, Uses, Production

Uses

GCN2-IN-7 (compound 39) is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor (IC50=5 nM). GCN2-IN-7 shows anti-tumor activity in vivo[1].

in vivo

GCN2-IN-7 (oral gavage; 15 mg/kg; BID; 17 d) shows robust target engagement in vivo at a reasonable dose[1].
GCN2-IN-7 (oral gavage; 50 mg/kg; BID; 17 d) inhibits tumor growth in vivo of the LL2 syngeneic mouse tumor model[1].

Animal Model:Balb/c mice injected with RENCA cells[1]
Dosage:15 mg/kg
Administration:Oral gavage; 15 mg/kg; BID; 17 days
Result:Showed robust target engagement of GCN2 in both tumor (average of 84%) and spleen (average of 80%) tissues.
Showed an average of 65% reduction of downstream marker Activation Transcription Factor 4 (ATF4) in compound-treated mice compared to the vehicle treatment group.
Animal Model:LL2 syngeneic mouse model[1]
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg; BID; 17 days
Result:Showed tumor growth inhibition (56%) after 26 days of dosing compared to the vehicle group.

References

[1] Jackson JJ, et al. Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy. J Med Chem. 2022 Sep 20. DOI:10.1021/acs.jmedchem.2c00736

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Pengque Chemical Technology Co., LTD 15317013857 15901926503 pengque01@sina.com China 977 58
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3075 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 19370895928 qqyang@aikonchem.com China 9995 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Supplier Advantage
TargetMol Chemicals Inc. 58
Shanghai Pengque Chemical Technology Co., LTD 58
Nantong Hi-Future Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58
Shanghai Amole Biotechnology Co., Ltd. 58

View Latest Price from Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GCN2-IN-7 pictures 2026-07-27 GCN2-IN-7
2396465-33-9
 $297.00-1230.00 99.47% 10g TargetMol Chemicals Inc.
  • GCN2-IN-7 pictures
  • GCN2-IN-7
    2396465-33-9
  • $297.00-1230.00
  • 99.47%
  • TargetMol Chemicals Inc.

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- Spectrum

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)-(2396465-33-9)1HNMR

2396465-33-9 (Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)-) Related Search:

Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- (S)-(-)-2-Azetidinecarboxylic acid HC-7366 2H-Indol-2-one, 3-cycloheptyl-1,3-dihydro-3-(4-hydroxyphenyl)-6-Methoxy-7-Methyl-, (3S)- ISRIB
eIF4A3-IN-2

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Cyclopentanecarboxamide, 3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethyl-, (1R,3R)- GCN2-IN-7 2396465-33-9