ChemicalBook >> CAS DataBase List >>Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl-

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl-

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- structure

CAS No.: 2247950-73-6

Chemical Name:: Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl-

Synonyms: Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl-

CBNumber:: CB212227992

Molecular Formula:: C22H19FN6

Molecular Weight:: 386.42

MDL Number:

MOL File:: 2247950-73-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:30

Request For Quotation

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- Properties

Density	1.37±0.1 g/cm3(Predicted)
pka	17.14±0.30(Predicted)
form	Solid
color	Off-white to light yellow

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0139747	KYN-101 98.03%	2247950-73-6	5mg	$195	2026-06-04	Buy
ChemScene	CS-0139747	KYN-101 98.03%	2247950-73-6	10mg	$303	2026-06-04	Buy
ChemScene	CS-0139747	KYN-101 98.03%	2247950-73-6	25mg	$563	2026-06-04	Buy
ChemScene	CS-0139747	KYN-101 98.03%	2247950-73-6	50mg	$867	2026-06-04	Buy
ChemScene	CS-0139747	KYN-101 98.03%	2247950-73-6	100mg	$1300	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0139747	5mg	$195	Buy
CS-0139747	10mg	$303	Buy
CS-0139747	25mg	$563	Buy
CS-0139747	50mg	$867	Buy
CS-0139747	100mg	$1300	Buy

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- Chemical Properties, Uses, Production

Uses

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity[1].

in vivo

KYN-101 (10 mg/kg; p.o.; daily for 12 days) shows anti-cancer activity in mice^[1].

Animal Model:	6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)^[1]
Dosage:	10 mg/kg
Administration:	P.o.; daily for 12 days
Result:	Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.

References

[1] Campesato LF, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020 Aug 11;11(1):4011. DOI:10.1038/s41467-020-17750-z

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- Suppliers

Global Suppliers ( 6)

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5985	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58
Zibo Hangyu Biotechnology Development Co., Ltd	13053322091 13053322091	admin@mopaikeji.com	China	1611	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
Aladdin Scientific		tp@aladdinsci.com	United States	50068	58

Supplier	Advantage
BOC Sciences	65
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- Spectrum

Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl-(2247950-73-6)¹HNMR

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Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl- 2247950-73-6