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ChemicalBook >> CAS DataBase List >>2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)-

2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)-

2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- Structure
2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- structure
CAS No.
2293951-01-4
Chemical Name:
2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)-
Synonyms
Anti-inflammatory agent 36;Anti-inflammatory agent 36, 10 mM in DMSO;1-((E)-3-(4-Hydroxy-3-methoxyphenyl)acryloyl)-3-((E)-3,4,5-trimethoxybenzylidene)piperidin-2-one;(E)-1-[(E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl]-3- (3,4,5-trimethoxybenzylidene) piperidin-2-one;2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)-
CBNumber:
CB212407116
Molecular Formula:
C25H27NO7
Molecular Weight:
453.48
MDL Number:
MOL File:
2293951-01-4.mol
Last updated:2025-09-11 22:01:37
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2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- Properties

Boiling point 633.9±55.0 °C(Predicted)
Density 1.272±0.06 g/cm3(Predicted)
form Solid
pka 9.71±0.31(Predicted)
color White to yellow

2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- Chemical Properties,Uses,Production

Uses

Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation[1].

in vivo

Anti-inflammatory agent 36 (Compound 5a28) (10 mg/kg, i.p.) inhibits inflammation in acute lung injury mouse model[1].

Animal Model:Acute lung injury mouse model[1]
Dosage:10 mg/kg
Administration:i.p.
Result:Reduced wet/dry weight ratio of the mice lungs.
Reduced biomarkers of lymphocytes and macrophages.
Suppresses TNF-α, IL-6, IL-1β, 7 VACM-1 and ICAM-1 level.

References

[1] Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425. DOI:10.1016/j.ejmech.2019.02.042

2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- Suppliers

Global( 10)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9979 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62320 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29547 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-58851090 17714375163 2881759498@qq.com China 13011 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
Bide Pharmatech Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58
Sangon Biotech (Shanghai) Co.,Ltd. 58

View Lastest Price from 2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Anti-inflammatory agent 36 pictures 2025-09-11 Anti-inflammatory agent 36
2293951-01-4
 US $43.00-143.00 / mg 99.47% 10g TargetMol Chemicals Inc.

2293951-01-4(2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)-)Related Search:

2-Piperidinone, 1-[(2E)-3-[4-(acetyloxy)-3-methoxyphenyl]-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)-
2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- Anti-inflammatory agent 36 (E)-1-[(E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl]-3- (3,4,5-trimethoxybenzylidene) piperidin-2-one Anti-inflammatory agent 36, 10 mM in DMSO 1-((E)-3-(4-Hydroxy-3-methoxyphenyl)acryloyl)-3-((E)-3,4,5-trimethoxybenzylidene)piperidin-2-one 2293951-01-4