3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
- CAS No.
- 64000-73-3
- Chemical Name:
- 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
- Synonyms
- propildazine;Propyldazine;1-[(6-Hydrazino-3-pyridazinyl)(methyl)amino]-2-propanol;2-Propanol, 1-[(6-hydrazinyl-3-pyridazinyl)methylamino]-;1-[(6-hydrazino-pyridazin-3-yl)-methyl-amino]-propan-2-ol;6-[(2-Hydroxypropyl)methylamino]-3(2H)-pyridazinone hydrazone;3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
- CBNumber:
- CB21242265
- Molecular Formula:
- C8H15N5O
- Molecular Weight:
- 197.24
- MDL Number:
- MFCD00865910
- MOL File:
- 64000-73-3.mol
- MSDS File:
- SDS
| FDA UNII | FU2BGC781U |
|---|
3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride Chemical Properties, Uses, Production
Uses
Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].
Definition
ChEBI: Pildralazine is a tertiary amino compound and a dialkylarylamine.
in vivo
Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay[1].
Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats[2].
Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model[3].
| Animal Model: | Male and female B6C3F1 and to female BALB/c mice (8 weeks old)[1] |
| Dosage: | 100, 200, and 400 ppm dose: 8, 20, and 40 mg/kg/day in B6C3F1 males, 8, 22, and 43 mg/kg/day in B6C3F1 females, and 6, 15, and 34 mg/kg/day in BALB/c females, respectively |
| Administration: | Oral gavage; added in the drinking water; provided for 80 weeks, and observed for 130-133 weeks age |
| Result: | Resulted over 80% of mice alive beyond 78 weeks of age. |
References
[1] Della Porta G, Dragani TA. Carcinogenicity study in mice on pildralazine, a hydralazinelike antihypertensive compound. J Cancer Res Clin Oncol. 1983;106(2):97-101. DOI:10.1007/BF00395386
[2] Chevillard C, et al. Interactions between hydralazine, propildazine and purines on arterial smooth muscle. Br J Pharmacol. 1981 Aug;73(4):811-7. DOI:10.1111/j.1476-5381.1981.tb08733.x
[3] Dorigotti L, et al. Effects of pildralazine alone and in combination on severe hypertension and cerebrovascular lesions in saline-drinking spontaneously hypertensive rats. Arzneimittelforschung. 1984;34(8):876-9. PMID:6541924
3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Pildralazine
64000-73-3
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- Pildralazine
64000-73-3
- $1520.00-2500.00
- TargetMol Chemicals Inc.
