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ChemicalBook >> CAS DataBase List >>18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)-

18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)-

18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)- Structure
18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)- structure
CAS No.
2700265-62-7
Chemical Name:
18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)-
Synonyms
Trk-IN-11;18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)-
CBNumber:
CB212469648
Molecular Formula:
C21H22FN5O3
Molecular Weight:
411.43
MDL Number:
MOL File:
2700265-62-7.mol
MSDS File:
SDS
Last updated:2026-05-11 16:31:51
Request For Quotation

18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)- Properties

Density 1.47±0.1 g/cm3(Predicted)
pka 10.65±0.60(Predicted)

18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)- Chemical Properties, Uses, Production

Uses

Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease[1].

IC 50

TrkA

References

[1] Fan Y, et al. Pyrizolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: Design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2022;63:128646. DOI:10.1016/j.bmcl.2022.128646

18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)- Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

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Trk-IN-11 pictures 2026-05-11 Trk-IN-11
2700265-62-7
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2700265-62-7 (18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)-) Related Search:

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Trk-IN-11 18,1-Metheno-6H-[1,4]oxazino[3,4-i]pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-15(12H)-one, 9-fluoro-3,4,13,14-tetrahydro-4,13,13-trimethyl-, (4R)- 2700265-62-7