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ChemicalBook >> CAS DataBase List >>(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Structure
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one structure
CAS No.
187523-35-9
Chemical Name:
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
Synonyms
MaxiPost;FLINDOKALNER;BMS-204352 (BMS 204352;Flindokalner BMS-204352;Flindokalner, 10 mM in DMSO;(S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one;(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one;(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one;2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-;inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current
CBNumber:
CB21253977
Molecular Formula:
C16H10ClF4NO2
Molecular Weight:
359.7
MDL Number:
MFCD09475617
MOL File:
187523-35-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-21 10:31:43
Product description Number Pack Size Price
BMS 204352 ≥98% (HPLC) SML1313 5mg $161
BMS 204352 ≥98% (HPLC) SML1313 25mg $796
BMS 204352 29378 1mg $37
BMS 204352 29378 10mg $266
BMS 204352 29378 5mg $142
Request For Quotation

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Properties

Boiling point 436.9±45.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
pka 10.43±0.40(Predicted)
form Powder
color White to off-white
InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChIKey ULYONBAOIMCNEH-HNNXBMFYSA-N
SMILES N1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O
FDA UNII J57O328W4W
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1313 BMS 204352 ≥98% (HPLC) 187523-35-9 5mg $161 2026-03-19 Buy
Sigma-Aldrich SML1313 BMS 204352 ≥98% (HPLC) 187523-35-9 25mg $796 2026-03-19 Buy
Cayman Chemical 29378 BMS 204352 187523-35-9 1mg $37 2024-03-01 Buy
Cayman Chemical 29378 BMS 204352 187523-35-9 10mg $266 2024-03-01 Buy
Cayman Chemical 29378 BMS 204352 187523-35-9 5mg $142 2024-03-01 Buy
Product number Packaging Price Buy
SML1313 5mg $161 Buy
SML1313 25mg $796 Buy
29378 1mg $37 Buy
29378 10mg $266 Buy
29378 5mg $142 Buy

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Chemical Properties,Uses,Production

Uses

Neuroprotectant (opener of large conductance, calcium-activated (maxi-K) K+channels.

Biological Activity

BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to tre at ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamily, member 4) and KCNQ5 (KQT-like subfamily, member 5) with equal potency.', 'BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.

in vivo

Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect[1].
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile[1].

Animal Model:Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)[1]
Dosage:i.p.
Administration:3, 10, 30 mg/kg
Result:Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.

storage

Store at +4°C

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one synthesis

206194-02-7
187523-35-9
Synthesis of (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Suppliers

Global( 43)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 88915 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44896 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58

View Lastest Price from (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Flindokalner pictures 2026-04-21 Flindokalner
187523-35-9
 US $32.00-113.00 / mg 99.96% 10g TargetMol Chemicals Inc.
  • Flindokalner pictures
  • Flindokalner
    187523-35-9
  • US $32.00-113.00 / mg
  • 99.96%
  • TargetMol Chemicals Inc.

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Spectrum

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one(187523-35-9)1HNMR
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one FLINDOKALNER MaxiPost (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one BMS-204352 (BMS 204352 2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)- Flindokalner BMS-204352 inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current (S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one Flindokalner, 10 mM in DMSO 187523-35-9 C16H10ClF4NO2