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ChemicalBook >> CAS DataBase List >>2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-

2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-

2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Structure
2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- structure
CAS No.
2217671-64-0
Chemical Name:
2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-
Synonyms
MIR002;2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-
CBNumber:
CB212619702
Molecular Formula:
C27H29NO5
Molecular Weight:
447.52
MDL Number:
MOL File:
2217671-64-0.mol
MSDS File:
SDS
Last updated:2026-05-11 16:31:51
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2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Properties

Density 1.303±0.06 g/cm3(Predicted)
form Solid
pka 4.49±0.10(Predicted)
color White to off-white

2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0435026 MIR002 99.0% 2217671-64-0 5mg $390 2026-06-04 Buy
ChemScene CS-0435026 MIR002 99.0% 2217671-64-0 10mg $639 2026-06-04 Buy
ChemScene CS-0435026 MIR002 99.0% 2217671-64-0 25mg $1278 2026-06-04 Buy
ChemScene CS-0435026 MIR002 99.0% 2217671-64-0 50mg $2058 2026-06-04 Buy
ChemScene CS-0435026 MIR002 99.0% 2217671-64-0 100mg $3358 2026-06-04 Buy
Product number Packaging Price Buy
CS-0435026 5mg $390 Buy
CS-0435026 10mg $639 Buy
CS-0435026 25mg $1278 Buy
CS-0435026 50mg $2058 Buy
CS-0435026 100mg $3358 Buy

2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Chemical Properties, Uses, Production

Uses

MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo[1].

in vivo

MIR002 (50 mg/kg; p.o.; twice a day for 5 days a week, 3 weeks) shows a good tolerability and antitumor activity (TGI=61%)[1].
MIR002 (50 mg/kg; p.o.; twice a day for 5 days a week, 6 weeks) shows an additive antitumor effect with complete disappearance of tumor masses in two animals at the end of the treatment when combination with cisplatin[1].
MIR002 ( 50 mg/kg, twice a day for 5 days) induces a significant increase of a interferon at its pharmacological active dose (50 mg/kg)[1].

Animal Model:Model: 4-6 weeks old female CD-1 nude mice (NSCLC NCI-H460 model)
Dosage:50 mg/kg
Administration:p.o.; twice a day for 5 days a week, 3 weeks
Result:Showed a good tolerability and antitumor activity (TGI=61%).
Animal Model:4-6 weeks old female CD-1 nude mice ( MM473-luc and MM487-Luc)[1]
Dosage:50 mg/kg combibnated with cisplatin (i.p.; 5 mg/kg; twice a day for 7 days a week, 6 weeks)
Administration:p.o.; twice a day for 5 days a week, 6 weeks
Result:Showed an additive antitumor effect with complete disappearance of tumor masses in two animals at the end of the treatment when combination with cisplatin.
Animal Model:4-6 weeks old female CD-1 nude mice (Melanoma B16 model)[1]
Dosage:50 mg/kg
Administration:p.o.; twice a day for 5 days
Result:Induced a significant increase of α interferon at its pharmacological active dose (50 mg/kg).

IC 50

HDAC11: 6.09 μM (IC50); POLA1

References

[1] Dallavalle S, et al. Antitumor activity of novel POLA1-HDAC11 dual inhibitors. Eur J Med Chem. 2022, 228:113971. DOI:10.1016/j.ejmech.2021.113971

2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- manufacturers

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MIR002 pictures 2026-05-11 MIR002
2217671-64-0
 $2140.00-3520.00 10g TargetMol Chemicals Inc.
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    2217671-64-0
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2217671-64-0 (2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-) Related Search:

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2-Propenoic acid, 3-[4'-[2-(hydroxyamino)-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- MIR002 2217671-64-0