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5-Chloro-2-phenoxyphenylacetic acid

5-Chloro-2-phenoxyphenylacetic acid structure

CAS No.: 70958-20-2

Chemical Name:: 5-Chloro-2-phenoxyphenylacetic acid

Synonyms: 2-(5-chloro-2-phenoxyphenyl)acetic acid;2-(5-Chloro-2-phenoxyphenyl);5-Chloro-2-phenoxyphenylacetic acid;5-Chloro-2-benzyloxyphenylaceticacid;5-Chloro-2-phenoxybenzeneacetic acid;2-(5-Chloro-2-phenoxyphenyl)aceticaci;Benzeneacetic acid, 5-chloro-2-phenoxy-;2-(5-chloro-2-phenoxyphenyl)acetic acid (en);5-Chloro-2-phenoxyphenylacetic acid Asenapine Int

CBNumber:: CB21263152

Molecular Formula:: C14H11ClO3

Molecular Weight:: 262.69

MDL Number:: MFCD07368830

MOL File:: 70958-20-2.mol

MSDS File:: SDS

Last updated:2026-05-27 23:54:54

Product description	Number	Pack Size	Price
2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	CS-M0225	10g	$64
2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	CS-M0225	25g	$133
2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	CS-M0225	100g	$357
2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	CS-M0225	5g	$3597
2-(5-Chloro-2-phenoxyphenyl)acetic acid	047905	500.00mg	$244
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5-Chloro-2-phenoxyphenylacetic acid Properties

Melting point	123-125°C
Boiling point	395.1±32.0 °C(Predicted)
Density	1.317±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	3.91±0.10(Predicted)
form	solid
Appearance	White to off-white Solid
InChI	InChI=1S/C14H11ClO3/c15-11-6-7-13(10(8-11)9-14(16)17)18-12-4-2-1-3-5-12/h1-8H,9H2,(H,16,17)
InChIKey	PKMKNEIUKHPJAX-UHFFFAOYSA-N
SMILES	C1(CC(O)=O)=CC(Cl)=CC=C1OC1=CC=CC=C1
UNSPSC Code	12352106
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
WGK Germany	WGK 3
HazardClass	IRRITANT
HS Code	2918999090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

5-Chloro-2-phenoxyphenylacetic acid price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-M0225	2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	70958-20-2	10g	$64	2026-06-04	Buy
ChemScene	CS-M0225	2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	70958-20-2	25g	$133	2026-06-04	Buy
ChemScene	CS-M0225	2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	70958-20-2	100g	$357	2026-06-04	Buy
ChemScene	CS-M0225	2-(5-Chloro-2-phenoxyphenyl)acetic acid ≥98%	70958-20-2	5g	$3597	2026-06-04	Buy
Matrix Scientific	047905	2-(5-Chloro-2-phenoxyphenyl)acetic acid	70958-20-2	500.00mg	$244	2026-05-18	Buy

Product number	Packaging	Price	Buy
CS-M0225	10g	$64	Buy
CS-M0225	25g	$133	Buy
CS-M0225	100g	$357	Buy
CS-M0225	5g	$3597	Buy
047905	500.00mg	$244	Buy

5-Chloro-2-phenoxyphenylacetic acid Chemical Properties,Uses,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 25, p. 855, 1982 DOI: 10.1021/jm00349a018

Synthesis

70958-18-8

70958-20-2

Example 14. Synthesis of 5-chloro-2-phenoxyphenylacetic acid (Compound XIVa) 200 g (0.81 mol) of 5-chloro-2-phenoxyacetophenone (Compound XV) obtained in Example 13, 112.3 g (1.29 mol) of morpholine, and 40 g (1.25 mol) of sulfur were mixed and the reaction was stirred at 110°C for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature and 1 L of glacial acetic acid and 1 L of concentrated aqueous hydrochloric acid were added sequentially, followed by continued stirring at reflux temperature for 8 hours. The reaction mixture was concentrated to about 1/3 of the original volume and then extracted by adding 800 mL of water and 800 mL of methyl tert-butyl ether. The aqueous layer was separated, washed with 400 mL of methyl tert-butyl ether and discarded. The organic phases were combined and washed sequentially with 500mL, 250mL, and 250mL of 8% aqueous sodium carbonate. All aqueous phases were combined and washed with 2 x 200 mL of methyl tert-butyl ether before adjusting the pH with concentrated hydrochloric acid to 1. 400 mL of petroleum ether was added and the mixture was stirred at room temperature for 30 min. The resulting suspension was filtered and the solid was dried to constant weight to give 143 g of 5-chloro-2-phenoxyphenylacetic acid (Compound XIVa) in 67.1% yield.

References

[1] Patent: EP2468751, 2012, A2. Location in patent: Page/Page column 21
[2] Journal of Medicinal Chemistry, 1982, vol. 25, # 7, p. 855 - 858
[3] Journal of Medicinal Chemistry, 1983, vol. 26, # 10, p. 1353 - 1360

5-Chloro-2-phenoxyphenylacetic acid Preparation Products And Raw materials

Raw materials

1-(5-chloro-2-phenoxyphenyl)ethanone Hydrochloric acid Acetic acid

Preparation Products

5-Chloro-2-phenoxyphenylacetic acid Suppliers

Global( 129)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	505	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15083	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Changzhou Ditong Chemical Co.,Ltd	58
Shochem(Shanghai) Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
AFINE CHEMICALS LIMITED	58

The role of 5-chloro-2-phenoxyphenylacetic acid as asenapine intermediate
5-chloro-2-phenoxyphenylacetic acid is the intermediate of asenapine synthesis, and Marco talked about the synthesis routes st....
Dec 23，2019

View Lastest Price from 5-Chloro-2-phenoxyphenylacetic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	5-Chloro-2-phenoxyphenylacetic acid 70958-20-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	5-Chloro-2-phenoxyphenylacetic acid 70958-20-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-10	5-Chloro-2-phenoxyphenylacetic acid 70958-20-2	$1.00	1KG	98%	150KG	Career Henan Chemical Co

5-Chloro-2-phenoxyphenylacetic acid
70958-20-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Chloro-2-phenoxyphenylacetic acid
70958-20-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Chloro-2-phenoxyphenylacetic acid
70958-20-2
$1.00
98%
Career Henan Chemical Co

5-Chloro-2-phenoxyphenylacetic acid Spectrum

5-Chloro-2-phenoxyphenylacetic acid(70958-20-2)¹³CNMR

70958-20-2(5-Chloro-2-phenoxyphenylacetic acid)Related Search:

trans-(+/-)-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one (5-CHLORO-2-METHOXYPHENYL)ACETIC ACID 2-PHENOXYPHENYLACETIC ACID 5-Chloro-2-phenoxyphenylacetic acid

5-Chloro-2-phenoxyphenylacetic acid 2-(5-chloro-2-phenoxyphenyl)acetic acid (en) Benzeneacetic acid, 5-chloro-2-phenoxy- 2-(5-Chloro-2-phenoxyphenyl) 2-(5-Chloro-2-phenoxyphenyl)aceticaci 5-Chloro-2-phenoxybenzeneacetic acid 5-Chloro-2-benzyloxyphenylaceticacid 5-Chloro-2-phenoxyphenylacetic acid Asenapine Int 2-(5-chloro-2-phenoxyphenyl)acetic acid 70958-20-2