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GS 283

GS 283 Structure
GS 283 structure
CAS No.
149440-36-8
Chemical Name:
GS 283
Synonyms
GS 283;7-Hydroxy-1-(4-Methoxybenzyl)-3,4-Dihydroisoquinolin-6(2H)-One;6,7-Isoquinolinediol, 3,4-dihydro-1-[(4-methoxyphenyl)methyl]-
CBNumber:
CB21308299
Molecular Formula:
C17H17NO3
Molecular Weight:
283.32
MDL Number:
MOL File:
149440-36-8.mol
MSDS File:
SDS
Last updated:2026-07-28 20:32:53
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GS 283 Properties

Boiling point 504.036±50.00 °C(Press: 760.00 Torr)(predicted)
Density 1.256±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 9.469±0.20(predicted)

GS 283 Chemical Properties, Uses, Production

Description

GS 283 is a Ca(2+) antagonist and a weak histamine & muscarinic receptor blocker in rat & guinea pig tracheal smooth muscles. Its mode of action is inhibition of calcium influx from plasma membrane & also release from sarcoplasmic reticulum.

Uses

GS 283 is a compound with calcium antagonist and weak histamine and muscarinic receptor blocking activity, with activity in modulating contraction of guinea pig and rat tracheal smooth muscle. GS 283 inhibits contractions induced by carbachol, histamine (guinea pig only), and high H+ in guinea pig and rat tracheal smooth muscle, inhibits Ca2+-induced contractions in guinea pig tracheal smooth muscle, and at high concentrations completely abolishes contractions induced by carbachol in Ca2+-free medium.

References

[1] Pharmacological characterization of effects of verapamil and GS 283 on isolated guinea pig and rat trachealis DOI:10.1016/0014-2999(93)90226-8

GS 283 Preparation Products And Raw materials

Raw materials

Preparation Products

GS 283 Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303 sales@changyanchem.cn China 4998 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29873 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
BOC Sciences 65
Shanghai Changyan Chem & Tech Co., Ltd. 55
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from GS 283 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GS 283 pictures 2026-05-11 GS 283
149440-36-8
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • GS 283 pictures
  • GS 283
    149440-36-8
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

149440-36-8 (GS 283) Related Search:

Thalsimidine Me ether (6,7-Dimethoxy-3,4-dihydro-1-isoquinolinyl)(3,4-dimethoxyphenyl)methanone Diproteverine AKOS AU36-M293 AKOS 212-100
1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinolinium chloride AKOS 223-03 AKOS AU36-M294 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline GS 283
AKOS 213-43 AKOS 220-16 3,4-Dihydro-6,7-diethoxy-1-((3,4-dipropoxyphenyl)methyl)isoquinoline h ydrochloride

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GS 283 6,7-Isoquinolinediol, 3,4-dihydro-1-[(4-methoxyphenyl)methyl]- 7-Hydroxy-1-(4-Methoxybenzyl)-3,4-Dihydroisoquinolin-6(2H)-One 149440-36-8