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ChemicalBook >> CAS DataBase List >>Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)-

Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)-

Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- Structure
Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- structure
CAS No.
2629192-96-5
Chemical Name:
Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)-
Synonyms
LRRK2/NUAK1/TYK2-IN-1;Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)-;5-(2,6-Difluorophenyl)-9-fluoro-8-(pyridazin-4-yl)-2,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine
CBNumber:
CB213163301
Molecular Formula:
C20H11F3N6
Molecular Weight:
392.34
MDL Number:
MOL File:
2629192-96-5.mol
Last updated:2025-10-28 16:00:23
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Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- Properties

Boiling point 744.9±60.0 °C(Predicted)
Density 1.57±0.1 g/cm3(Predicted)
pka 12.95±0.20(Predicted)

Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- Chemical Properties,Uses,Production

Uses

LRRK2/NUAK1/TYK2-IN-1 (conpound 226) shows inhibitory activity toward LRRK2 (Wt), LRRK2 (G2019), TYK2 and NUAK1, with IC50 values lower than 10 nM. LRRK2/NUAK1/TYK2-IN-1 can be used for autoimmune disease research[1].

IC 50

Tyk2; NUAK1

References

[1] Roland Koestler, et al. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease. Patent WO2021048618A1.

Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LRRK2/NUAK1/TYK2-IN-1 pictures 2025-10-27 LRRK2/NUAK1/TYK2-IN-1
2629192-96-5
 US $1520.00-2500.00 / mg 10g TargetMol Chemicals Inc.
Pyrazolo[4,3-d][1,3]benzodiazepine, 5-(2,6-difluorophenyl)-9-fluoro-2,4-dihydro-8-(4-pyridazinyl)- 5-(2,6-Difluorophenyl)-9-fluoro-8-(pyridazin-4-yl)-2,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine LRRK2/NUAK1/TYK2-IN-1 2629192-96-5