4-Bromo-5-methyl-2-thiophenecarboxylic acid
- CAS No.
- 29421-99-6
- Chemical Name:
- 4-Bromo-5-methyl-2-thiophenecarboxylic acid
- Synonyms
- 4-BROMO-5-METHYLTHIOPHENE-2-CARBOXYLIC ACID;AKOS B029947;VITAS-BB TBB010222;ART-CHEM-BB B029947;4-Bromo-5-methyl-2-thiophenecarboxylic acid;2-Thiophenecarboxylic acid, 4-bromo-5-methyl-
- CBNumber:
- CB2133164
- Molecular Formula:
- C6H5BrO2S
- Molecular Weight:
- 221.07
- MDL Number:
- MFCD01859873
- MOL File:
- 29421-99-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H302-H315-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
4-Bromo-5-methyl-2-thiophenecarboxylic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS140542 | 4-Bromo-5-methylthiophene-2-carboxylic acid 97% | 29421-99-6 | 1g | $56 | 2026-06-04 | Buy |
| Activate Scientific | AS140542 | 4-Bromo-5-methylthiophene-2-carboxylic acid 97% | 29421-99-6 | 5g | $150 | 2026-06-04 | Buy |
| Synthonix | B42699 | 4-Bromo-5-methylthiophene-2-carboxylic acid 97% | 29421-99-6 | 100mg | $26 | 2026-05-06 | Buy |
| Synthonix | B42699 | 4-Bromo-5-methylthiophene-2-carboxylic acid 97% | 29421-99-6 | 250mg | $32 | 2026-05-06 | Buy |
| Synthonix | B42699 | 4-Bromo-5-methylthiophene-2-carboxylic acid 97% | 29421-99-6 | 1g | $40 | 2026-05-06 | Buy |
4-Bromo-5-methyl-2-thiophenecarboxylic acid Chemical Properties,Uses,Production
Synthesis
29421-73-6
29421-99-6
a) 27.65 g (108 mmol) of 2-methyl-3,5-dibromothiophene (prepared according to the method of Kano, S. et al, Heterocycles 20(10):2035, 1983) was dissolved in 280 mL of anhydrous tetrahydrofuran and cooled to -78°C. To this solution was added, over a 10-minute period, 54 mL (108 mmol) of a 2 M n-butyllithium in cyclohexane solution. After stirring at -78°C for 20 min, dry carbon dioxide gas was passed into the reaction system for 1.5 hr while the mixture was allowed to warm slowly to room temperature. Upon completion of the reaction, 100 mL of 6N hydrochloric acid was carefully added. The organic and aqueous layers were separated and the aqueous layer was extracted with ether (4 x 50 mL). All organic layers were combined, washed with brine and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 22.4 g (94% yield) of 4-bromo-5-methylthiophene-2-carboxylic acid as an off-white solid.1H-NMR (DMSO-d6; 300 MHz) δ 13.34 (br s, 1H), 7.61 (s, 1H), 2.41 (s, 3H).
References
[1] Patent: US2002/37915, 2002, A1
[2] Patent: US6291514, 2001, B1
[3] Justus Liebigs Annalen der Chemie, 1934, vol. 513, p. 281,291
4-Bromo-5-methyl-2-thiophenecarboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
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| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
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| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Shanghai Sealing Biotechnology Co. Ltd.. | 15721176654;15710104046 | 1815535157@qq.com | China | 984 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
