KS 505a
- CAS No.
- 131774-53-3
- Chemical Name:
- KS 505a
- Synonyms
- KS 505a;Longestin;β-D-Glucopyranosiduronic acid, (1R,2S,4R,4aR,4bS,6R,6aS,6bS,8aR,8bS,10aS,17aS,17bR,19aS,19bR,21aS,21bS,23aR)-1-carboxy-2,3,4,4a,4b,5,6,6a,6b,7,8,8a,8b,9,10,10a,14,16,17,17a,17b,18,19,19a,19b,20,21,21a,21b,22,23,23a-dotriacontahydro-14-hydroxy-8a,10a-bis(hydroxymethyl)-14-(3-methoxy-3-oxopropyl)-1,4,...
- CBNumber:
- CB21346671
- Molecular Formula:
- C61H88O17
- Molecular Weight:
- 1093.35
- MDL Number:
- MFCD32263214
- MOL File:
- 131774-53-3.mol
KS 505a Chemical Properties, Uses, Production
Description
Longestin is a trypanocidal agent; isolated from Steptomyces argenteolus; inhibits brain calcium- and calmodulin-dependent cyclic nucleotide phosphodiesterase.
Uses
Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent[1][2].
References
[1] Ozaki T, et al. Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit. Angew Chem Int Ed Engl. 2018 May 28;57(22):6629-6632. DOI:10.1002/anie.201802116
[2] Hayashi Y, et al. Cloning of the gene cluster responsible for biosynthesis of KS-505a (longestin), a unique tetraterpenoid. Biosci Biotechnol Biochem. 2007 Dec;71(12):3072-81. DOI:10.1271/bbb.70477
KS 505a Preparation Products And Raw materials
Raw materials
Preparation Products
KS 505a Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
