ABBV-467
- CAS No.
- 2287186-66-5
- Chemical Name:
- ABBV-467
- Synonyms
- ABBV-467;18,21-Etheno-9,13-metheno-13H-6,14,17-trioxa-2-thia-3,5-diazacyclononadec[cd]indene-7-carboxylic acid, 19,23-dichloro-10-[[2-[4-[(2R)-1,4-dioxan-2-ylmethoxy]phenyl]-4-pyrimidinyl]methoxy]-1-(4-fluorophenyl)-7,8,15,16-tetrahydro-20,22-dimethyl-16-[(4-methyl-1-piperazinyl)methyl]-, (7R,16R)-
- CBNumber:
- CB213765778
- Molecular Formula:
- C53H51Cl2FN6O9S
- Molecular Weight:
- 1037.98
- MDL Number:
- MOL File:
- 2287186-66-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
ABBV-467 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 44289 | ABBV-467 ≥98% | 2287186-66-5 | 1mg | $270 | 2026-04-30 | Buy |
| ChemScene | CS-0904288 | ABBV-467 99.78% | 2287186-66-5 | 1mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0904288 | ABBV-467 99.78% | 2287186-66-5 | 5mg | $677 | 2026-06-04 | Buy |
| ChemScene | CS-0904288 | ABBV-467 99.78% | 2287186-66-5 | 10mg | $1083 | 2026-06-04 | Buy |
ABBV-467 Chemical Properties, Uses, Production
Uses
ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].
in vivo
ABBV-467 (12.5 mg/kg, i.v., once per week for 3 weeks) exhibits significant antitumor activity in t(4;14)-translocated multiple myeloma mouse models[1].
| Animal Model: | t(4;14) (chromosomal translocation between chromosome 4 and chromosome 14)-translocated high-risk multiple myeloma NOD-SCID mice[1] |
| Dosage: | 6.25 mg/kg and 12.5 mg/kg |
| Administration: | Intravenous injection (i.v.), once per week for 3 weeks |
| Result: | Resulted in a maximal tumor delay of 82% at 6.25 mg/kg and complete tumor regression at 12.5 mg/kg. |
References
[1] Yuda J, et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond). 2023 Oct 25;3(1):154. DOI:10.1038/s43856-023-00380-z
ABBV-467 Preparation Products And Raw materials
Raw materials
Preparation Products
ABBV-467 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Aikon International Limited | 025-58859352 18651614124 | 2881516338@qq.com | China | 9968 | 58 |
| Supplier | Advantage |
|---|---|
| Nantong QuanYi Biotechnology Co., Ltd | 58 |
| Aikon International Limited | 58 |
