NH125
- CAS No.
- 278603-08-0
- Chemical Name:
- NH125
- Synonyms
- NH125 ，S7436;NH125 USP/EP/BP;NH125, 10 mM in DMSO;EEF-2 KINASE INHIBITOR;NH 125, CaMK III inhibitor;eEF-2 Kinase Inhibitor, NH125;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;3-benzyl-1-decahexalkaneyl-2-methyl-1H-imidazole-3-iodo;1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem
- CBNumber:
- CB9503988
- Molecular Formula:
- C27H45N2.I
- Molecular Weight:
- 524.567
- MDL Number:
- MFCD07370143
- MOL File:
- 278603-08-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 88.2-94.9 °C |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL |
| form | solid |
| color | white to off-white |
| InChI | 1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1 |
| InChIKey | RVWOHCBHAGBLLT-UHFFFAOYSA-M |
| SMILES | [I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
NH125 price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N2162 | NH125 ≥98% (HPLC), solid | 278603-08-0 | 5mg | $407 | 2026-04-30 | Buy |
| Cayman Chemical | 10011250 | NH125 ≥95% | 278603-08-0 | 1mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 10011250 | NH125 ≥95% | 278603-08-0 | 5mg | $130 | 2026-04-30 | Buy |
| Cayman Chemical | 10011250 | NH125 ≥95% | 278603-08-0 | 10mg | $173 | 2026-04-30 | Buy |
| Cayman Chemical | 10011250 | NH125 ≥95% | 278603-08-0 | 25mg | $376 | 2026-04-30 | Buy |
NH125 Chemical Properties, Uses, Production
Uses
NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus.
Biological Activity
Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo .
Biochem/physiol Actions
NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.
IC 50
CaMK III: 60 nM (IC50)
storage
Desiccate at -20°C
References
[1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68.
NH125 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Target molecule Corp. | 857-239-0968 | service1@targetmol.com | United States | 2548 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9792 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
