ovatodiolide
- CAS No.
- 3484-37-5
- Chemical Name:
- ovatodiolide
- Synonyms
- Nsc156130;Nsc 272353;Melampodin;ovatodiolide;11H-13,10-Methenofuro[2,3-f]oxacyclopentadecin-2,11(3H)-dione, 3a,4,5,8,9,13,14,16a-octahydro-6,15-dimethyl-3-methylene-, (3aS,6E,13S,15E,16aR)-
- CBNumber:
- CB21386729
- Molecular Formula:
- C20H24O4
- Molecular Weight:
- 328.4
- MDL Number:
- MFCD30180062
- MOL File:
- 3484-37-5.mol
- MSDS File:
- SDS
| Cosmetics Ingredients Functions |
SKIN CONDITIONING - MISCELLANEOUS ANTIOXIDANT ANTIMICROBIAL |
|---|---|
| InChI | InChI=1S/C20H24O4/c1-12-5-4-6-15-11-16(23-20(15)22)9-13(2)10-18-17(8-7-12)14(3)19(21)24-18/h5,10-11,16-18H,3-4,6-9H2,1-2H3/b12-5+,13-10+/t16-,17-,18+/m0/s1 |
| InChIKey | KTYZKXFERQUCPX-SIKGVNBJSA-N |
| SMILES | O1C(=O)C2=C[C@]1([H])CC(C)=C[C@@]1([H])OC(=O)C(=C)[C@]1([H])CCC(C)=CCC2 |t:10,25| |
| FDA UNII | 641ILF0QGZ |
ovatodiolide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0077907 | Ovatodiolide 99.70% | 3484-37-5 | 1mg | $303 | 2026-06-04 | Buy |
| ChemScene | CS-0077907 | Ovatodiolide 99.70% | 3484-37-5 | 5mg | $753 | 2026-06-04 | Buy |
| Biorbyt Ltd | orb1702993 | Ovatodiolide 99.65% | 3484-37-5 | 1mg | $240 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1702993 | Ovatodiolide 99.65% | 3484-37-5 | 5mg | $530 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1702993 | Ovatodiolide 99.65% | 3484-37-5 | 10mg | $740 | 2026-05-06 | Buy |
ovatodiolide Chemical Properties, Uses, Production
Description
Ovatodiolide (OV) is a bioactive phytochemical purified from Anisomeles indica (L.) Kuntze (Labiatae) is a medicinal herb that has been widely used to treat a variety of inflammation-associated diseases. Ovatodiolide has been reported to exhibit many biological functions, including anti-cancer, anti-bacterial, and anti-HIV activities. Most importantly, the studies have demonstrated that ovatodiolide inhibited H. pylori-induced inflammation in gastric epithelial cells[1-2].
Uses
Ovatodiolide is a compound that can be isolated from Anisomeles indica. Ovatodiolide has anti-bacterial and anti-inflammatory properties. Ovatodiolide also has anti-cancer activity that induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways[1].
Biological Functions
Various oncogenic targets inhibited by ovatodiolide have been implicated; these include TNF-α, NF-κB, β-catenin, MMPs, and others to achieve anti-cancer effects such as the induction of cell cycle arrest, apoptosis, and reduction of metastatic potential. Ovatodiolide suppressed cell colony formation and induced apoptosis in the K562 and KU812 cells. Ovatodiolide enhanced the production of reactive oxygen species (ROS), activated Nrf2 signaling, and inhibited mTOR phosphorylation. Autophagic flux was enhanced after treatment with ovatodiolide in K562 cells. Furthermore, autophagy inhibition alleviated ovatodiolide-induced cell apoptosis, whereas autophagy promotion aggravated apoptosis in CML cells. These results demonstrated that ovatodiolide activates autophagy-mediated cell death in CML cells.
Additionally, ovatodiolide transcriptionally activated the expression of p62, and the p62 levels were negatively regulated by autophagy. Moreover, p62-Keap1-Nrf2 signaling was confirmed to be involved in ovatodiolide-induced cell death. Accordingly, LC3B knockdown augmented the ovatodiolide-induced p62 expression, increased the p62-Keap1 interaction, and enhanced the translocation of Nrf2 into the nucleus. In contrast, p62 inhibition abolished the effects induced through ovatodiolide treatment. Nrf2 inhibition with ML385 diminished the protective effect of autophagy inhibition in CML cells. Collectively, ovatodiolide induces oxidative stress and provokes autophagy, effectively decreasing the expression of p62 and weakening the protective effect of Nrf2 signaling activation, thus contributing to apoptosis in CML cells[2].
Toxicity evaluation
In the bacterial reverse mutation assay and the mammalian chromosome aberration assay, ovatodiolide was non-mutagenic with or without the addition of the S9 fraction. In the micronucleus assay, ovatodiolide did not cause an increase in micronucleated reticulocytes. The acute oral toxicity of ovatodiolide in rats exceeded 1000 mg/kg bw. In addition, ovatodiolide at 10, 25, and 50 mg/kg bw did not produce significant effects in rats[3].
References
[1] Hsiu-Man Lien. “Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori.” Scientific Reports (2019): 4205.
[2] Qingqing Xia . “Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.” Chemico-Biological Interactions 387 (2023): Article 110819.
[3] JING-CHUN CHEN. Genotoxicity and 28-day repeated dose oral toxicity study of ovatodiolide in rats.[J]. Toxicology Reports, 2021: 1783-1791. DOI:10.1016/j.toxrep.2021.10.010.
ovatodiolide Preparation Products And Raw materials
Raw materials
Preparation Products
ovatodiolide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Tianjin Shangde Medicine Edge Technology Co., Ltd | 13370460931 | sales@accendatech.com | China | 11 | 58 |
| Hangzhou FuRun Pharmaceutical Technology Co., Ltd | 15658004993 | 1900830611@qq.com | China | 980 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +86-15658003402 | sales@newcanbio.com | China | 1979 | 58 |
| Hunan ravel Biotechnology Co.,Ltd | 18627957289 18173226957 | 3628571360@qq.com | China | 3000 | 58 |
| Hunan ravel Biotechnology Co.,Ltd | 18086085632 | 435918333@qq.com | China | 1927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shengbaolai Biotechnology Co., Ltd | 027-86-027-59105235 15527244834 | shengblai@126.com | China | 488 | 58 |
View Latest Price from ovatodiolide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Ovatodiolide
3484-37-5
|
$195.00-692.00 | 99.65% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-13 | ovatodiolide
3484-37-5
|
1g | 98 | 1000g | Shaanxi Dideu New Materials Co. Ltd |
-
- Ovatodiolide
3484-37-5
- $195.00-692.00
- 99.65%
- TargetMol Chemicals Inc.
-
- ovatodiolide
3484-37-5
- $0.00
- 98
- Shaanxi Dideu New Materials Co. Ltd
