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QS 21

QS 21 structure

CAS No.: 141256-04-4

Chemical Name:: QS 21

Synonyms: CL130;QA 21;QS 21;QA 21V1;QS-21-Api;QS-21 saponin;QS-21 ADJUVANT;Saponin QA 21V1;Ak-bioPower? QS 21;Sapindus mukorossi saponin

CBNumber:: CB21396474

Molecular Formula:: C92H148O46

Molecular Weight:: 1990.13

MDL Number:: MFCD00938543

MOL File:: 141256-04-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:55:57

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QS 21 Properties

Density	1.52±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Store at -20°C
pka	2.68±0.70(Predicted)
form	Solid
color	White to light yellow
InChIKey	CNEYUDLWGDOPIY-VWDQBTOUNA-N
FDA UNII	61H83WZX3U
NCI Dictionary of Cancer Terms	QS21
NCI Drug Dictionary	QS21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H319
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P

QS 21 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	XQ184377	QS 21	141256-04-4	10mg	$1650	2026-06-05	Buy
Biosynth	XQ184377	QS 21	141256-04-4	25mg	$2647	2026-06-05	Buy
Biosynth	XQ184377	QS 21	141256-04-4	50mg	$3987.5	2026-06-05	Buy
Biosynth	XQ184377	QS 21	141256-04-4	100mg	$6188	2026-06-05	Buy
Biosynth	XQ184377	QS 21	141256-04-4	500mg	$13750	2026-06-05	Buy

Product number	Packaging	Price	Buy
XQ184377	10mg	$1650	Buy
XQ184377	25mg	$2647	Buy
XQ184377	50mg	$3987.5	Buy
XQ184377	100mg	$6188	Buy
XQ184377	500mg	$13750	Buy

QS 21 Chemical Properties,Uses,Production

Uses

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].

in vivo

Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively^[3].

IC 50

NLRP3 inflammasome

References

[1] Fernández-Tejada A, et al. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Acc Chem Res. 2016;49(9):1741-1756. DOI:10.1021/acs.accounts.6b00242
[2] Marty-Roix R, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291(3):1123-1136 DOI:10.1074/jbc.M115.683011
[3] Lacaille-Dubois MA. Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review. Phytomedicine. 2019;60:152905. DOI:10.1016/j.phymed.2019.152905

QS 21 Preparation Products And Raw materials

Raw materials

Preparation Products

QS 21 Suppliers

Global( 70)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hunan Furui Biopharma Technology Co., Ltd.	15901640172，19275032510 15901640172	sales03@hn-furui.com	China	380	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4861	55
Wuhan ChemFaces Biochemical Co., Ltd.	18607101326 15172504745	aileen@chemfaces.com	China	6904	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28150	68
Chengdu Push Bio-Technology Co., Ltd.	028-85370565-229 18080489829	18080489829@163.com	China	8379	60
Shanghai Zhen Li Biological Technology Co., Ltd	021-16621358918; 18516310516;16621358918;13045646768	zhenlipharma888@163.com	China	19060	58
Nanjing crow LuNing pharmaceutical technology co., LTD	13382066392		CHINA	4851	58
Beijing OKA biological technology co., LTD	010-62971590 18548936886	3462612863@qq.com	China	10061	58

Supplier	Advantage
Hunan Furui Biopharma Technology Co., Ltd.	55
Bide Pharmatech Ltd.	60
Shanghai Lollane Biological Technology Co.,Ltd.	55
Wuhan ChemFaces Biochemical Co., Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Chengdu Push Bio-Technology Co., Ltd.	60
Shanghai Zhen Li Biological Technology Co., Ltd	58
Nanjing crow LuNing pharmaceutical technology co., LTD	58
Beijing OKA biological technology co., LTD	58

View Lastest Price from QS 21 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-25	QS-21 141256-04-4				10g	TargetMol Chemicals Inc.

QS-21
141256-04-4
$0.00
TargetMol Chemicals Inc.

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QS 21 QS-21 ADJUVANT QA 21 QA 21V1 QS-21-Api Saponin QA 21V1 β-D-Glucopyranosiduronic acid, (3β,4α,16α)-28-[[O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-4-O-[5-[[5-(α-L-arabinofuranosyloxy)-3-hydroxy-6-methyl-1-oxooctyl]oxy]-3-hydroxy-6-methyl-1-oxooctyl]-6-deoxy-β-D-galactopyranosyl]oxy]-16-hydroxy-23,28-dioxoole... (2S,3S,4S,5R,6R)-6-(((3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-((((2S,3R,4S,5R,6R)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-(((3S,5S,6S)-5-(((3S,5S,6S)-5-(((2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3-h QS-21 saponin (2S,3S,4S,5R,6R)-6-(((3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-((((2S,3R,4S,5R,6R)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-(((3S,5S,6S)-5-(((3S,5S,6S)-5-(((2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3-hydroxy-6-methyloctanoyl)oxy)-3-hydroxy-6-methyloctanoyl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)carbonyl)-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,1 Ak-bioPower? QS 21 Sapindus mukorossi saponin CL130 141256-04-4 C92H148O46