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ChemicalBook >> CAS DataBase List >>[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base)

[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base)

[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Structure
[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) structure
CAS No.
Chemical Name:
[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base)
Synonyms
Ala11,D-Leu15]-Orexin B acetate
CBNumber:
CB214314063
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2026-07-30 10:48:35
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[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Properties

solubility PBS (pH 7.2): 1 mg/ml
Water: Soluble

[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 36728 [Ala11,D-Leu15]-Orexin B (acetate) ≥98% 500μg $219 2026-04-30 Buy
Cayman Chemical 36728 [Ala11,D-Leu15]-Orexin B (acetate) ≥98% 1mg $394 2026-04-30 Buy
Cayman Chemical 36728 [Ala11,D-Leu15]-Orexin B (acetate) ≥98% 5mg $1314 2026-04-30 Buy
Product number Packaging Price Buy
36728 500μg $219 Buy
36728 1mg $394 Buy
36728 5mg $1314 Buy

[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Chemical Properties, Uses, Production

Description

[Ala11,D-Leu15]-Orexin B is a synthetic peptide agonist of the orexin 2 (OX2) receptor.1 It selectively induces calcium mobilization in CHO-K1 cells expressing OX2 over CHO-K1 cells expressing OX1 (EC50s = 0.13 and 52 nM, respectively, for the human receptors). [Ala11,D-Leu15]-Orexin B inhibits forskolin-, PACAP (1-27)-, or VIP-induced cAMP formation in primary rat neuronal cells (IC50s = 42, 32.3, and 22.9 nM, respectively).2 It increases mean arterial pressure (MAP), heart rate, and phrenic nerve activity in rats when intracranially administered at a dose of 0.75 pmol/animal.3WARNING This product is not for human or veterinary use.

References

[1] SHUICHI ASAHI. Development of an orexin-2 receptor selective agonist, [Ala11, d-Leu15]orexin-B[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 1: Pages 111-113. DOI: 10.1016/s0960-894x(02)00851-x
[2] ANNA URBAŃSKA. Orexins/Hypocretins Acting at Gi Protein-Coupled OX2 Receptors Inhibit Cyclic AMP Synthesis in the Primary Neuronal Cultures[J]. Journal of Molecular Neuroscience, 2011, 46 1: 10-17. DOI: 10.1007/s12031-011-9526-2
[3] ISRAT Z SHAHID  Paul M P  Ahmed A Rahman. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex[J]. British Journal of Pharmacology, 2011, 165 7: 2292-2303. DOI: 10.1111/j.1476-5381.2011.01694.x

[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Preparation Products And Raw materials

Raw materials

Preparation Products

[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Suppliers

Global Suppliers ( 4)
Supplier Tel Email Country ProdList Advantage
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
TargetMol 58
TargetMol Chemicals Inc. 58

View Latest Price from [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
[Ala11,D-Leu15]-Orexin B acetate pictures 2026-07-29 [Ala11,D-Leu15]-Orexin B acetate
$248.00-848.00 98.18% 10g TargetMol Chemicals Inc.

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Ala11,D-Leu15]-Orexin B acetate