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[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) manufacturers
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| | [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Basic information |
| | [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Chemical Properties |
| solubility | PBS (pH 7.2): 1 mg/ml
Water: Soluble |
| | [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Usage And Synthesis |
| Description | [Ala11,D-Leu15]-Orexin B is a synthetic peptide agonist of the orexin 2 (OX2) receptor.1 It selectively induces calcium mobilization in CHO-K1 cells expressing OX2 over CHO-K1 cells expressing OX1 (EC50s = 0.13 and 52 nM, respectively, for the human receptors). [Ala11,D-Leu15]-Orexin B inhibits forskolin-, PACAP (1-27)-, or VIP-induced cAMP formation in primary rat neuronal cells (IC50s = 42, 32.3, and 22.9 nM, respectively).2 It increases mean arterial pressure (MAP), heart rate, and phrenic nerve activity in rats when intracranially administered at a dose of 0.75 pmol/animal.3WARNING This product is not for human or veterinary use. | | References | [1] SHUICHI ASAHI. Development of an orexin-2 receptor selective agonist, [Ala11, d-Leu15]orexin-B[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 1: Pages 111-113. DOI: 10.1016/s0960-894x(02)00851-x
[2] ANNA URBAŃSKA. Orexins/Hypocretins Acting at Gi Protein-Coupled OX2 Receptors Inhibit Cyclic AMP Synthesis in the Primary Neuronal Cultures[J]. Journal of Molecular Neuroscience, 2011, 46 1: 10-17. DOI: 10.1007/s12031-011-9526-2
[3] ISRAT Z SHAHID Paul M P Ahmed A Rahman. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex[J]. British Journal of Pharmacology, 2011, 165 7: 2292-2303. DOI: 10.1111/j.1476-5381.2011.01694.x |
| | [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) Preparation Products And Raw materials |
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