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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE structure

CAS No.: 38385-95-4

Chemical Name:: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE

Synonyms: 2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE;2-Piperdin-4-yl-1H-benziomidazole;2-(PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE;2-Piperdin-4-yl-1H-benziomimidazole;AKOS BBS-00005832;CHEMBRDG-BB 4003376;TIMTEC-BB SBB002504;Bilastine impurity H;OTAVA-BB BB7020410139;Bilasten intermediate 1

CBNumber:: CB2146618

Molecular Formula:: C12H15N3

Molecular Weight:: 201.27

MDL Number:: MFCD01475843

MOL File:: 38385-95-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-12 19:08:34

Product description	Number	Pack Size	Price
2-(4-Piperidinyl)benzimidazole >98.0%(GC)	P2382	1g	$106
2-(4-Piperidinyl)benzimidazole >98.0%(GC)	P2382	5g	$314
2-Piperidin-4-yl-1H-benzoimidazole Asreported	287352	250mg	$379
2-Piperidin-4-yl-1H-benzoimidazole Asreported	287352	500mg	$545
2-Piperidin-4-yl-1H-benzoimidazole Asreported	287352	1g	$761
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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Properties

Melting point	230 °C (decomp)(Solv: water (7732-18-5))
Boiling point	441.3±38.0 °C(Predicted)
Density	1.167±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
form	Solid
pka	11.83±0.10(Predicted)
color	White to Light yellow to Light orange
λmax	279nm(MeOH)(lit.)
InChI	InChI=1S/C12H15N3/c1-2-4-11-10(3-1)14-12(15-11)9-5-7-13-8-6-9/h1-4,9,13H,5-8H2,(H,14,15)
InChIKey	HBOGHPAOOWUTLB-UHFFFAOYSA-N
SMILES	C1(C2CCNCC2)NC2=CC=CC=C2N=1
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes	Xi
HS Code	2933.99.8290
HazardClass	IRRITANT
REACH Registrations	Active

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2382	2-(4-Piperidinyl)benzimidazole >98.0%(GC)	38385-95-4	1g	$106	2026-04-30	Buy
TCI Chemical	P2382	2-(4-Piperidinyl)benzimidazole >98.0%(GC)	38385-95-4	5g	$314	2026-04-30	Buy
Usbiological	287352	2-Piperidin-4-yl-1H-benzoimidazole Asreported	38385-95-4	250mg	$379	2026-06-03	Buy
Usbiological	287352	2-Piperidin-4-yl-1H-benzoimidazole Asreported	38385-95-4	500mg	$545	2026-06-03	Buy
Usbiological	287352	2-Piperidin-4-yl-1H-benzoimidazole Asreported	38385-95-4	1g	$761	2026-06-03	Buy

Product number	Packaging	Price	Buy
P2382	1g	$106	Buy
P2382	5g	$314	Buy
287352	250mg	$379	Buy
287352	500mg	$545	Buy
287352	1g	$761	Buy

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Chemical Properties,Uses,Production

Chemical Properties

2-(4-piperidinyl)-1H-benzimidazole is white or brownish-yellow solid under normal temperature and pressure, with good solubility in methanol.

Uses

2-Piperidin-4-yl-1H-benzimidazole is used as a reagent in the synthesis of 3-amino-1-(5-indanyloxy)-2-propanol derivatives as potent sodium channel blockers for the treatment of ischemic stroke. Also used as a reagent in the synthesis of 2,3,5-trisubstituted pyridine derivatives as potent Akt1/Akt2 dual inhibitors.

Synthesis

498-94-2

95-54-5

38385-95-4

The general procedure for the synthesis of 2-(4-piperidinyl)-1H-benzimidazole from 4-piperidinecarboxylic acid and o-phenylenediamine was as follows: according to the method described in the literature (J. Heterocyclic Chem., 1989, 26, 54), benzene-1,2-diamine (12.6 g, 116 mmol) was mixed with piperidine-4-carboxylic acid (15 g, 116 mmol) in a 4M HCl aqueous solution (250 mL), stirred and heated under reflux conditions for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to alkaline with 5 M NaOH aqueous solution. The precipitate precipitated was collected by filtration, washed with water and subsequently dried in a vacuum oven to afford the target product 2-(piperidin-4-yl)-1H-benzimidazole 8.8 g in 38% yield. Mass spectrometry analysis showed m/z = 202 [M+ + H].

References

[1] Patent: US6660751, 2003, B1. Location in patent: Page column 7,8
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 3, p. 695 - 699
[3] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 707 - 718
[4] Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 541 - 543
[5] Patent: WO2010/80357, 2010, A1. Location in patent: Page/Page column 41-42

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Preparation Products And Raw materials

Raw materials

Isonipecotic acid o-Phenylenediamine Sodium hydroxide Hydrochloric acid

Preparation Products

tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Suppliers

Global( 290)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	288	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3955	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Xiamen Shindano Biotechnology Co.,ltd	0592-6266840 15750707980	sales@chemsdano.com	China	291	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Xiamen Shindano Biotechnology Co.,ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-30	2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 38385-95-4	$100.00-2000.00	1KG	98%	5MT per month	Anhui Dexinjia Biopharm Co., Ltd
2026-06-30	2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 38385-95-4		1kg	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
2026-06-08	2-Piperdin-4-yl-1H-Benzimidazole 38385-95-4		1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
38385-95-4
$100.00-2000.00
98%
Anhui Dexinjia Biopharm Co., Ltd

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
38385-95-4
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2-Piperdin-4-yl-1H-Benzimidazole
38385-95-4
99%
Jinan Ruitong Biotech Co., Ltd.

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Spectrum

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE(38385-95-4)¹HNMR

38385-95-4(2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE)Related Search:

2-PIPERIDIN-3-YL-1H-BENZOIMIDAZOLE 1-METHYL-2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE 6-BROMO-2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE alinastine

5-FLUORO-2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE,5-Fuoro-2-piperidin-4-yl-1H-benzoimidazole 6-METHYL-2-(PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE 5-METHYL-2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 5-FLUORO-2-PIPERIDIN-2-YL-1H-BENZOIMIDAZOLE 5-Methoxy-2-piperidin-3-yl-1H-benzoimidazole hydrochloride

2-PIPERIDIN-2-YL-1H-BENZOIMIDAZOLE 5-Fluoro-2-piperidin-4-yl-1H-benzoimidazole HYDROCHLORIDE 5-FLUORO-2-PIPERIDIN-3-YL-1H-BENZOIMIDAZOLE 2-Piperidin-4-yl-1H-benzoimidazole hydrochloride 5-Methoxy-2-piperidin-4-yl-1H-benzoimidazole hydrochloride

5-Methoxy-2-piperidin-2-yl-1H-benzoimidazole hydrochloride 5-Fluoro-2-piperidin-3-yl-1H-benzoimidazole hydrochloride 2-Piperidin-2-yl-1H-benzoimidazole hydrochloride

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AKOS BBS-00005832 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 2-(4-PIPERIDYL)-1H-1,3-BENZIMIDAZOLE OTAVA-BB BB7020410139 TIMTEC-BB SBB002504 2-(4-piperidinyl)-1H-benzimidazole CHEMBRDG-BB 4003376 2-piperidin-4-yl-1H-benzimidazole(SALTDATA: 2HCl 0.5H2O) 1H-BenziMidazole,2-(4-piperidinyl)- 2-(4-Piperidyl)-1H-benzoimidazole Bilasten intermediate 1 Bilastine impurity H 2-(4-Piperidinyl)benzimidazole 2-Piperdin-4-yl-1H-Benzimidazole 2-(4-piperidine) -1H-benzimidazole 1-(4- Piperidinyl ) benzimidazole Hydrocortisone Acetate Impurity 1 (Hydrocortisone Acetate EP Impurity A) 2-(Piperidin-4-yl)-1H-benzo[d]imidazole (Bilastine Impurity) 2-(PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE 2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE 2-Piperdin-4-yl-1H-benziomidazole 2-Piperdin-4-yl-1H-benziomimidazole 38385-95-4