Methylene boldenone
- CAS No.
- 122370-91-6
- Chemical Name:
- Methylene boldenone
- Synonyms
- (17β)-;METHYLENE BOLDENONE;17β-Hydroxy Exemestane;17--Hydroxy Exemestane;Impurity H in ezetimibe;Exemestane 17β-Hydroxy Impurity;17β-Hydroxy ExeMestane SulfaMate;Exemestane Impurity 23 (Exemestane EP Impurity H);(17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;(17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
- CBNumber:
- CB21478037
- Molecular Formula:
- C20H26O2
- Molecular Weight:
- 298.42
- MDL Number:
- MOL File:
- 122370-91-6.mol
- MSDS File:
- SDS
| Melting point | 134-136°C |
|---|---|
| Density | 1.14 |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White |
| CAS DataBase Reference | 122370-91-6 |
| FDA UNII | U35ZNO9DJH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H361 | |||||||||
| Precautionary statements | P201-P202-P264-P280-P305+P351+P338-P308+P313-P337+P313-P405-P501 | |||||||||
| NFPA 704 |
|
Methylene boldenone price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27989 | 17β-hydroxy Exemestane ≥98% | 122370-91-6 | 1mg | $336 | 2026-04-30 | Buy |
| Cayman Chemical | 27989 | 17β-hydroxy Exemestane | 122370-91-6 | 5mg | $848 | 2024-03-01 | Buy |
| TRC | TRC-H942340-5MG | 17-beta-Hydroxy Exemestane >95%(HPLC) | 122370-91-6 | 5mg | $907 | 2026-06-03 | Buy |
| TRC | TRC-H942340-1MG | 17-beta-Hydroxy Exemestane >95%(HPLC) | 122370-91-6 | 1mg | $225 | 2026-06-03 | Buy |
| Usbiological | 013801 | 17β-Hydroxy Exemestane | 122370-91-6 | 1mg | $523 | 2026-06-03 | Buy |
Methylene boldenone Chemical Properties, Uses, Production
Description
17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.
Chemical Properties
Off-White Solid
Uses
A metabolite of Exemestane; exerts biological effects as an androgen.
Uses
17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).
References
[1] PAUL E GOSS. Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats.[J]. Clinical Cancer Research, 2004, 10 17: 5717-5723. DOI: 10.1158/1078-0432.ccr-04-0438
[2] LANDRY K KAMDEM Z D David A Flockhart. In vitro cytochrome P450-mediated metabolism of exemestane.[J]. Drug Metabolism and Disposition, 2011, 39 1: 98-105. DOI: 10.1124/dmd.110.032276
[3] FRANCO BUZZETTI . Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione)[J]. Steroids, 1993, 58 11: Pages 527-532. DOI: 10.1016/0039-128x(93)90029-m
[4] ERIC A ARIAZI. Exemestane’s 17-hydroxylated metabolite exerts biological effects as an androgen.[J]. Molecular Cancer Therapeutics, 2007: 2817-2827. DOI: 10.1158/1535-7163.mct-07-0312
[5] CARLA L. VARELA . Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line[J]. European Journal of Medicinal Chemistry, 2014, 87: Pages 336-345. DOI: 10.1016/j.ejmech.2014.09.074
Methylene boldenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-4000505016 13380397412 | 3001272453@qq.com | China | 5000 | 50 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1949 | 55 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shijiazhuang yaoBo Pharmaceutical Co., Ltd. | 15633056635 | 2880679888@qq.com | China | 2796 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-63315541 13323832564 | 1443871971@qq.com | China | 9896 | 58 |
View Latest Price from Methylene boldenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | 17β-hydroxy Exemestane
122370-91-6
|
$658.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-12-22 | 17β-hydroxy Exemestane
122370-91-6
|
$658.00 | 10g | TargetMol Chemicals Inc. |
-
- 17β-hydroxy Exemestane
122370-91-6
- $658.00
- TargetMol Chemicals Inc.
-
- 17β-hydroxy Exemestane
122370-91-6
- $658.00
- TargetMol Chemicals Inc.
