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NMS-P626

NMS-P626 Structure
NMS-P626 structure
CAS No.
942471-37-6
Chemical Name:
NMS-P626
Synonyms
NMS-P626;Benzamide, N-[5-[(3,5-difluorophenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-2-[[(1R)-2-methoxy-1-methylethyl]amino]-4-(4-methyl-1-piperazinyl)-
CBNumber:
CB214907944
Molecular Formula:
C28H35F2N7O4S
Molecular Weight:
603.69
MDL Number:
MOL File:
942471-37-6.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:52
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NMS-P626 Properties

Density 1.396±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 12.545±0.20(predicted)

NMS-P626 Chemical Properties, Uses, Production

Uses

NMS-P626 is an inhibitor of TRKA, TRKB, and TRKC, with IC50 values of 8 nM, 7 nM, and 3 nM, respectively. NMS-P626 inhibits the growth of KM12 cells by suppressing the phosphorylation of TPM3-TRKA and downstream signaling in KM12 cells, with an IC50 of 19 nM for KM12 cells. NMS-P626 can be used in colorectal cancer research[1].

IC 50

TrkA: 8 nM (IC50); TrkB: 3 nM (IC50); TrkC: 7 nM (IC50)

References

[1] Ardini E, et al. The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition. Mol Oncol. 2014 Dec;8(8):1495-507. DOI:10.1016/j.molonc.2014.06.001

NMS-P626 Preparation Products And Raw materials

Raw materials

Preparation Products

NMS-P626 Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
TargetMol Chemicals Inc. 58

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NMS-P626 Benzamide, N-[5-[(3,5-difluorophenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-2-[[(1R)-2-methoxy-1-methylethyl]amino]-4-(4-methyl-1-piperazinyl)- 942471-37-6