4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
- CAS No.
- 136624-42-5
- Chemical Name:
- 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
- Synonyms
- 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE;4-amino-1-(phenylmethyl)-4-piperidinecarbonitrile;4-Piperidinecarbonitrile, 4-amino-1-(phenylmethyl)-
- CBNumber:
- CB21519196
- Molecular Formula:
- C13H17N3
- Molecular Weight:
- 215.29
- MDL Number:
- MFCD09042612
- MOL File:
- 136624-42-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE 95% | 52150 | 0.25G | $59 |
| 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE 95% | 52150 | 1G | $200 |
| 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE 95% | 52150 | 5G | $787 |
| 4-Amino-1-benzylpiperidine-4-carbonitrile 95% | AS111118 | 1g | $351 |
| 4-Amino-1-benzylpiperidine-4-carbonitrile | 145291 | 250.00mg | $533 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 52150 | 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE 95% | 136624-42-5 | 0.25G | $59 | 2026-04-30 | Buy |
| AstaTech | 52150 | 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE 95% | 136624-42-5 | 1G | $200 | 2026-04-30 | Buy |
| AstaTech | 52150 | 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE 95% | 136624-42-5 | 5G | $787 | 2026-04-30 | Buy |
| Activate Scientific | AS111118 | 4-Amino-1-benzylpiperidine-4-carbonitrile 95% | 136624-42-5 | 1g | $351 | 2026-06-04 | Buy |
| Matrix Scientific | 145291 | 4-Amino-1-benzylpiperidine-4-carbonitrile | 136624-42-5 | 250.00mg | $533 | 2026-05-18 | Buy |
4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Chemical Properties,Uses,Production
Synthesis
773837-37-9
3612-20-2
136624-42-5
Step A: Synthesis of 4-amino-1-benzylpiperidine-4-carbonitrile To a solution of ammonium chloride (17.3 g, 323 mmol) in water (200 mL) was sequentially added 25% ammonia (25 mL, 332 mmol) and 1-benzylpiperidin-4-one (11.43 g, 60 mmol). The resulting mixture was stirred at room temperature for 20 minutes, followed by the addition of sodium cyanide (14.7 g, 300 mmol) in batches over 15 minutes. The reaction mixture was stirred at room temperature for 24 hours and then partitioned between water (200 mL) and dichloromethane (2 x 200 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (silica gel, elution gradient: 50% ethyl acetate/heptane to 100% ethyl acetate) to afford 4-amino-1-benzylpiperidine-4-carbonitrile (6.15 g, 47% yield). 1H NMR (300 MHz, CDCl3) δ ppm: 1.69-1.86 (m, 4H), 2.00 (dt, J = 13.1, 2.1 Hz, 2H), 2.27-2.45 (m, 2H), 2.83 (dt, J = 12.4, 3.6 Hz, 2H), 3.55 (s, 2H), 7.21-7.39 (m. 5H); MS m/z 216 (M + H)+.
References
[1] ACS Combinatorial Science, 2016, vol. 18, # 6, p. 330 - 336
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4719 - 4722
[3] Patent: WO2014/39769, 2014, A1. Location in patent: Page/Page column 286-287
[4] Patent: US2015/99730, 2015, A1. Location in patent: Paragraph 0723; 0724
[5] Patent: US2010/130506, 2010, A1. Location in patent: Page/Page column 108
4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1996 | 58 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8693 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 400821072 | malulu@leyan.com | China | 24933 | 58 |
| Nanjing SynTitan Pharmaceutical Co., Ltd. | 025-57027686 17372956142 | li_lan@syntitan.com | China | 9999 | 58 |
